Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
…, JF Schindler, DB Reitz, RJ Mourey - Journal of medicinal …, 2007 - ACS Publications
A new class of potent kinase inhibitors selective for mitogen-activated protein kinase-activated
protein kinase 2 (MAPKAP-K2 or MK-2) for the treatment of rheumatoid arthritis has been …
protein kinase 2 (MAPKAP-K2 or MK-2) for the treatment of rheumatoid arthritis has been …
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory …
RJ Mourey, BL Burnette, SJ Brustkern… - … of Pharmacology and …, 2010 - ASPET
Activation of the p38 kinase pathway in immune cells leads to the transcriptional and
translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated …
translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated …
Efferent connections of the centromedian and parafascicular thalamic nuclei: an autoradiographic investigation in the cat
GJ Royce, RJ Mourey - Journal of comparative Neurology, 1985 - Wiley Online Library
The efferent projections of the centromedian and parafascicular (CM‐Pf) thalamic nuclear
complex were analyzed by the autoradiographic method. Our findings show that the CM‐Pf …
complex were analyzed by the autoradiographic method. Our findings show that the CM‐Pf …
A simple, sensitive, and specific radioreceptor assay for inositol 1, 4, 5-trisphosphate in biological tissues
DS Bredt, RJ Mourey, SH Snyder - Biochemical and biophysical research …, 1989 - Elsevier
Inositol (1,4,5)P 3 (IP 3 ) receptors in rat cerebellar membranes have been used to develop
a radioreceptor assay for endogenous IP 3 . The assay is sensitive, detecting as little as 1 …
a radioreceptor assay for endogenous IP 3 . The assay is sensitive, detecting as little as 1 …
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase
…, RM Weier, GJ Hanson, RJ Mourey… - Journal of medicinal …, 2007 - ACS Publications
A series of pyrazole inhibitors of p38 mitogen-activated protein (MAP) kinase were designed
using a binding model based on the crystal structure of 1 (SC-102) bound to p38 enzyme. …
using a binding model based on the crystal structure of 1 (SC-102) bound to p38 enzyme. …
Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation.
LJ Mauro, EA Olmsted, BM Skrobacz, RJ Mourey… - Journal of Biological …, 1994 - ASBMB
Absence of the tyrosine kinase activity of c-src and c-fms results in impairment of bone
remodeling. Such dysfunction underscores the importance of tyrosine phosphorylation, yet the …
remodeling. Such dysfunction underscores the importance of tyrosine phosphorylation, yet the …
Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency
…, SA Long, BS Pierce, MW Mahoney, RJ Mourey… - Bioorganic & Medicinal …, 2009 - Elsevier
Optimization of kinase selectivity for a set of benzothiophene MK2 inhibitors provided analogs
with potencies of less than 500nM in a cell based assay. The selectivity of the inhibitors …
with potencies of less than 500nM in a cell based assay. The selectivity of the inhibitors …
[HTML][HTML] A Novel Cytoplasmic Dual Specificity Protein Tyrosine Phosphatase Implicated in Muscle and Neuronal Differentiation (∗)
RJ Mourey, QC Vega, JS Campbell… - Journal of Biological …, 1996 - ASBMB
Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine
phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). In …
phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). In …
Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potency
…, SA Long, BS Pierce, MW Mahoney, RJ Mourey - Bioorganic & Medicinal …, 2009 - Elsevier
Identification of potent benzothiophene inhibitors of mitogen activated protein kinase-activated
protein kinase 2 (MK2), structure–activity relationship (SAR) studies, selectivity …
protein kinase 2 (MK2), structure–activity relationship (SAR) studies, selectivity …
Tethered ip3. Synthesis and biochemical applications of the 1-o-(3-aminopropyl) ester of inositol (1, 4, 5)-trisphosphate
GD Prestwich, JF Marecek, RJ Mourey… - Journal of the …, 1991 - ACS Publications
A phosphodiester analogue of the second messenger Ins (l, 4, 5) P3 has been synthesized
and used to prepare a novel photoaffinity label and a selective bioaffinity matrix. A selectively …
and used to prepare a novel photoaffinity label and a selective bioaffinity matrix. A selectively …