Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea
M Unemo, RA Nicholas - Future microbiology, 2012 - Future Medicine
The new superbug Neisseria gonorrhoeae has retained resistance to antimicrobials previously
recommended for first-line treatment and has now demonstrated its capacity to develop …
recommended for first-line treatment and has now demonstrated its capacity to develop …
[PDF][PDF] Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP-and UTP-specific …
RA Nicholas, WC Watt, ER Lazarowski, Q Li… - Molecular …, 1996 - Citeseer
Observation that the G protein-coupled P2 receptor(P2Y2 receptor) is activated by UTP as
well as ATP provided the first indication that a class of uridine nucleotide-responsive receptors …
well as ATP provided the first indication that a class of uridine nucleotide-responsive receptors …
Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance …
…, M Hu, M Olesky, RA Nicholas - Antimicrobial agents and …, 2002 - Am Soc Microbiol
Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part
through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane …
through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane …
Invisible water, visible impact: groundwater use and Indian agriculture under climate change
…, DH Wrenn, A Prusevich, RE Nicholas - Environmental …, 2016 - iopscience.iop.org
India is one of the world's largest food producers, making the sustainability of its agricultural
system of global significance. Groundwater irrigation underpins India's agriculture, currently …
system of global significance. Groundwater irrigation underpins India's agriculture, currently …
[HTML][HTML] Physiological Regulation of ATP Release at the Apical Surface of Human Airway Epithelia*♦
SF Okada, RA Nicholas, SM Kreda… - Journal of biological …, 2006 - ASBMB
Extracellular ATP and its metabolite adenosine regulate mucociliary clearance in airway
epithelia. Little has been known, however, regarding the actual ATP and adenosine …
epithelia. Little has been known, however, regarding the actual ATP and adenosine …
Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
WL Veal, RA Nicholas, WM Shafer - Journal of bacteriology, 2002 - Am Soc Microbiol
The importance of the mtrCDE-encoded efflux pump in conferring chromosomally mediated
penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using …
penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using …
Porin-Mediated Antibiotic Resistance in Neisseria gonorrhoeae: Ion, Solute, and Antibiotic Permeation through PIB Proteins with penB Mutations
…, S Zhao, RL Rosenberg, RA Nicholas - Journal of …, 2006 - Am Soc Microbiol
Neisseria gonorrhoeae has two porins, PIA and PIB, whose genes (porA and porB,
respectively) are alleles of a single por locus. We recently demonstrated that penB mutations at …
respectively) are alleles of a single por locus. We recently demonstrated that penB mutations at …
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1‐purinoceptor
…, Q Li, JL Boyer, RA Nicholas… - British journal of …, 1996 - Wiley Online Library
1 . The coding sequence of the P 2Y1 ‐purinoceptor was cloned from a human genomic library.
2 . The open reading frame encodes a protein of 373 amino acids that is 83% identical to …
2 . The open reading frame encodes a protein of 373 amino acids that is 83% identical to …
Identification and Analysis of Amino Acid Mutations in Porin IB That Mediate Intermediate-Level Resistance to Penicillin and Tetracycline in Neisseria gonorrhoeae
M Olesky, M Hobbs, RA Nicholas - Antimicrobial agents and …, 2002 - Am Soc Microbiol
PenB is the third resistance determinant in the stepwise acquisition of multiple resistance
genes in chromosomally mediated resistant Neisseria gonorrhoeae (CMRNG). Alterations in …
genes in chromosomally mediated resistant Neisseria gonorrhoeae (CMRNG). Alterations in …
Genetics of Chromosomally Mediated Intermediate Resistance to Ceftriaxone and Cefixime in Neisseria gonorrhoeae
All strains of Neisseria gonorrhoeae with reduced susceptibility to ceftriaxone and cefixime (cephalosporin-intermediate-resistant
[Ceph i ] strains) contain a mosaic penA allele …
[Ceph i ] strains) contain a mosaic penA allele …