A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils
D Claessen, R Rink, W de Jong, J Siebring… - Genes & …, 2003 - genesdev.cshlp.org
Streptomycetes exhibit a complex morphological differentiation. After a submerged
mycelium has been formed, filaments grow into the air to septate into spores. A class of eight …
mycelium has been formed, filaments grow into the air to septate into spores. A class of eight …
Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog
LD Kluskens, SA Nelemans, R Rink, L de Vries… - … of Pharmacology and …, 2009 - ASPET
The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic
degradation. Cyclization of these therapeutic peptides is an excellent way to render them more …
degradation. Cyclization of these therapeutic peptides is an excellent way to render them more …
[HTML][HTML] NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non …
A Kuipers, E de Boef, R Rink, S Fekken… - Journal of biological …, 2004 - ASBMB
Lantibiotics are lanthionine-containing peptide antibiotics. Nisin, encoded by nisA, is a
pentacyclic lantibiotic produced by some Lactococcus lactis strains. Its thioether rings are …
pentacyclic lantibiotic produced by some Lactococcus lactis strains. Its thioether rings are …
Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation
R Rink, J Wierenga, A Kuipers… - Applied and …, 2007 - Am Soc Microbiol
Nisin A is a pentacyclic antibiotic peptide produced by various Lactococcus lactis strains.
Nisin displays four different activities: (i) it autoinduces its own synthesis; (ii) it inhibits the …
Nisin displays four different activities: (i) it autoinduces its own synthesis; (ii) it inhibits the …
Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin
LD Kluskens, A Kuipers, R Rink, E de Boef… - Biochemistry, 2005 - ACS Publications
Post-translationally introduced dehydroamino acids often play an important role in the activity
and receptor specificity of biologically active peptides. In addition, a dehydroamino acid …
and receptor specificity of biologically active peptides. In addition, a dehydroamino acid …
Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes
R Rink, A Kuipers, E de Boef, KJ Leenhouts… - Biochemistry, 2005 - ACS Publications
Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines are
posttranslationally introduced into the prepropeptides by biosynthetic enzymes that …
posttranslationally introduced into the prepropeptides by biosynthetic enzymes that …
[HTML][HTML] The X-ray structure of epoxide hydrolase from Agrobacterium radiobacter AD1: an enzyme to detoxify harmful epoxides
…, IS Ridder, HJ Rozeboom, KH Kalk, R Rink… - Journal of biological …, 1999 - ASBMB
Epoxide hydrolases catalyze the cofactor-independent hydrolysis of reactive and toxic
epoxides. They play an essential role in the detoxification of various xenobiotics in higher …
epoxides. They play an essential role in the detoxification of various xenobiotics in higher …
[HTML][HTML] Primary structure and catalytic mechanism of the epoxide hydrolase from Agrobacterium radiobacterAD1
R Rink, M Fennema, M Smids, U Dehmel… - Journal of biological …, 1997 - ASBMB
The epoxide hydrolase gene fromAgrobacterium radiobacter AD1, a bacterium that is able
to grow on epichlorohydrin as the sole carbon source, was cloned by means of the …
to grow on epichlorohydrin as the sole carbon source, was cloned by means of the …
Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage
A Plat, LD Kluskens, A Kuipers, R Rink… - Applied and …, 2011 - Am Soc Microbiol
Nisin A is a pentacyclic peptide antibiotic produced by Lactococcus lactis. The leader
peptide of prenisin keeps nisin inactive and has a role in inducing NisB- and NisC-catalyzed …
peptide of prenisin keeps nisin inactive and has a role in inducing NisB- and NisC-catalyzed …
[HTML][HTML] Phage display and selection of lanthipeptides on the carboxy-terminus of the gene-3 minor coat protein
…, T Aumüller, M Thein, T Bosma, R Rink… - Nature …, 2017 - nature.com
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an emerging
class of natural products with drug-like properties. To fully exploit the potential of RiPPs as …
class of natural products with drug-like properties. To fully exploit the potential of RiPPs as …