The effects of several naturally occurring and synthetic flavonoids on the metabolism of
benzo(a)pyrene and aflatoxin B 1 were evaluated. Addition of apigenin, chrysin, fisetin, flavanone…

Commercial grade curcumin (∼77% curcumin, 17% demethoxycurcumin and 3%
bisdemethoxycurcumin) is widely used as a yellow coloring agent and spice in foods. In the present …

Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit
the mutagenicity and cytotoxicity of (±)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-…

Studies by several investigators have shown that 12–0-tetradecanoylphorbol-13-acetate (TPA)
is an extraordinarily potent stimulator of differentiation of cultured human promyelocytic …

I had the good fortune of coming to the McArdle Laboratory for Cancer Research in 1952 as
a graduate student of James and Elizabeth Miller.* The Millers tried very hard to instill their …

Fifty-two patients with solid tumors had depressed white blood cell and neutrophil counts
because of prior treatment with cytotoxic cancer chemotherapeutic drugs. These patients were …

The effect of ellagic acid and some of its more lipophilk derivatives on the mutagenicity of (±
)-7β, 8α-di-hydroxy-9α 10α-epoxy-7, 8, 910-etrahydrobenz[a]pyrene was examined in …

Twenty-nine benzo(a)pyrene derivatives were tested for mutagenic activity without metabolic
activation in Salmonella typhimurium strains TA98, TA100, and TA1538 and in Chinese …

Four benzo-ring epoxides of the environmental carcinogen benzo(a)pyrene (BP) were tested
for mutagenic and cytotoxic activity in 3 strains of Salmonella typhimurium (TA1538, TA98, …

Expression of c-jun was observed in normally Proliferating JB6 cells but not in confluent
cells. Reduction of the serum concentration from 5% to 2% in the cell culture medium caused …