User profiles for Richard B. Mailman
Richard MailmanUniversity Distinguished Professor and College of Medicine Distinguished Senior Scholar Verified email at psu.edu Cited by 17925 |
Functional selectivity and classical concepts of quantitative pharmacology
The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century, yet
recent data have revealed that many ligands can differentially activate signaling pathways …
recent data have revealed that many ligands can differentially activate signaling pathways …
Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?
RB Mailman, V Murthy - Current pharmaceutical design, 2010 - ingentaconnect.com
Functional selectivity is the term that describes drugs that cause markedly different signaling
through a single receptor (eg, full agonist at one pathway and antagonist at a second). It has …
through a single receptor (eg, full agonist at one pathway and antagonist at a second). It has …
Serotonergic basis of antipsychotic drug effects in schizophrenia
JA Lieberman, RB Mailman, G Duncan, L Sikich… - Biological …, 1998 - Elsevier
Recent attention has been focused on the involvement of serotonin (5-HT) in the pathophysiology
of schizophrenia and its role in mediating antipsychotic drug effects. There are two …
of schizophrenia and its role in mediating antipsychotic drug effects. There are two …
Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes
…, AM Gonzalez, DR Sibley, RB Mailman - …, 1999 - Elsevier
OPC-14597 {aripiprazole; 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone}
is a novel candidate antipsychotic that has high affinity for striatal …
is a novel candidate antipsychotic that has high affinity for striatal …
Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease
The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD)
and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that …
and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that …
[HTML][HTML] Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways
Aripiprazole is a unique atypical antipsychotic drug with an excellent side-effect profile
presumed, in part, to be due to lack of typical D 2 dopamine receptor antagonist properties. …
presumed, in part, to be due to lack of typical D 2 dopamine receptor antagonist properties. …
GPCR functional selectivity has therapeutic impact
RB Mailman - Trends in pharmacological sciences, 2007 - cell.com
Many in vitro data show that some ligands can cause the differential activation of signaling
pathways mediated by a single receptor (termed ‘functional selectivity'). It remains unclear, …
pathways mediated by a single receptor (termed ‘functional selectivity'). It remains unclear, …
trans-10, 11-dihydroxy-5, 6, 6a, 7, 8, 12b-hexahydrobenzo [a] phenanthridine: a highly potent selective dopamine D1 full agonist
…, TW Lovenberg, MH Lewis, RB Mailman - Journal of medicinal …, 1990 - ACS Publications
… The adenylate cyclase assay is as described by Schulz and Mailman.47 Hill coefficients
for … The lowest energy of these is illustrated in Figure 2A, with the B ring in a pseudochair …
for … The lowest energy of these is illustrated in Figure 2A, with the B ring in a pseudochair …
Projection of the prevalence of Parkinson's disease in the coming decades: Revisited
Objective Previous studies have estimated future PD prevalence based on population aging.
This study revisits that projection by accounting for the potential impact of declining rates of …
This study revisits that projection by accounting for the potential impact of declining rates of …
Quantitative susceptibility mapping of the midbrain in Parkinson's disease
Background Parkinson's disease (PD) is marked pathologically by dopamine neuron loss
and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to …
and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to …