Pentylenetetrazole (PTZ) is a central nervous system convulsant that is thought, based on
binding studies, to act at the picrotoxin (PTX) site of the γ-aminobutyric acid type A (GABA A ) …

purpose. The ς-1 receptor belongs to a recently discovered family of transmembrane proteins
expressed in the central nervous system, including the eye, and mediates the regulation of …

L-type voltage-gated Ca 2+ channels (VGCC) play an important role in dendritic development,
neuronal survival, and synaptic plasticity. Recent studies have demonstrated that the …

Anecdotal reports have surfaced concerning misuse of the HIV antiretroviral medication
efavirenz ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2, 4-dihydro-1H-3, 1-…

Background and Purpose Cognitive deficits in patients with A lzheimer's disease, P arkinson's
disease, traumatic brain injury and stroke often involve alterations in cholinergic signalling…

We studied the effects of extracellular pH (pH o ) on γ-aminobutyric acid (GABA)–mediated
Cl − current in rat hypothalamic neurons and recombinant type-A GABA (GABA A ) receptors …

The protein tyrosine kinase (PTK) inhibitor genistein has been widely used to examine
potential effects of tyrosine phosphorylation on neurotransmitter function. We report here that …

Efavirenz is highly effective at suppressing HIV-1, and the WHO guidelines list it as a component
of the first-line antiretroviral (ARV) therapies for treatment-naïve patients. Though the …

In the present study, rundown of γ-aminobutyric acid (GABA)-activated Cl − channels was
studied in recombinant GABA A receptors stably expressed in human embryonic kidney cells (…

Genistein, a tyrosine kinase inhibitor, has been widely used to examine potential effects of
protein tyrosine kinase (PTK)-mediated regulation of receptor/channel function. Alteration of …