Most general anaesthetics and classical benzodiazepine drugs act through positive modulation
of γ-aminobutyric acid type A (GABA A ) receptors to dampen neuronal activity in the …

E1 enzymes initiate ubiquitin-like protein (ubl) transfer cascades by catalyzing adenylation
of the ubl's C terminus. An E1's selectivity for its cognate ubl is essential because the E1 …

Mangrove forests are highly productive tidal saline wetland ecosystems found along sheltered
tropical and subtropical coasts. Ecologists have long assumed that climatic drivers (ie, …

Heptapeptides containing residues with terminal olefin-derivatized side chains (3 and 4)
have been treated with ruthenium alkylidene 1 and undergone facile ring-closing olefin …

γ-Aminobutyric acid type A (GABA A ) receptors are pentameric ligand-gated ion channels
abundant in the central nervous system and are prolific drug targets for treating anxiety, sleep …

Documentation over a 28-year period of beaver (Castor canadensis) habitat use permitted
development and testing of two models to predict maximum density of active beaver colonies …

Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I Ks current
and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences …

Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between the …

Ethanol alters nerve signalling by interacting with proteins in the central nervous system,
particularly pentameric ligand-gated ion channels. A recent series of mutagenesis experiments …

The effects of increased salinity on plant growth were examined in a greenhouse experiment
with four species common to oligohaline marshes of the northern Gulf of Mexico: Eleocharis …