Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals
including drugs and endogenous substances. Although it is usually the secondary metabolic …

Hematopoietic stem cells (HSCs) remain mostly quiescent under steady-state conditions but
switch to a proliferative state following hematopoietic stress, eg, bone marrow (BM) injury, …

Mitochondrial metabolites regulate leukaemic and normal stem cells by affecting epigenetic
marks. How mitochondrial enzymes localize to the nucleus to control stem cell function is …

The purpose of this research was to develop a sensitive and reproducible UPLC–MS/MS
method to simultaneously quantify genistein, genistein-7-O-glucuronide (G-7-G), genistein-4′-…

We characterized the isoform specific glucuronidation of six isoflavones, genistein, daidzein,
glycitein, formononetin, biochanin A and prunetin, using 12 expressed human UGTs and …

The purposes of this study were to investigate how efflux transporters and UDP-glucuronosyltransferases
(UGT) affect the disposition of naringenin. A rat intestinal perfusion model with …

Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues
in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its …

The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a
critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell …

Leukemic stem cells (LSCs) rely on oxidative metabolism and are differentially sensitive to
targeting mitochondrial pathways, which spares normal hematopoietic cells. A subset of …

Copper and zinc act as a cofactor of over 300 mammalian proteins. Both have same electronic
configuration therefore they are antagonist at higher individual concentration. The present …