The cytokine transforming growth factor (TGF)-β, by virtue of its immunosuppressive and
promigratory properties, has become a major target for the experimental treatment of human …

Diabetes can induce a bewildering list of sensory changes, including alteration in pain
sensitivity. Painful diabetic neuropathy is refractory to most common analgesics. This study …

Destruction of cartilage and bone is a poorly managed hallmark of human rheumatoid
arthritis (RA). p38 Mitogen-activated protein kinase (MAPK) has been shown to regulate key …

Long-term exposure of sexually mature female rhesus monkeys (Macaca mulata) to thrice
weekly injections of Δ 9 -tetrahydrocannabinol resulted in a disruption of menstrual cycles that …

Oral Δ9‐tetrahydrocannabinol (THC) in gelatin capsules is under evaluation as an antiemetic
agent in cancer patients, but knowledge concerning its bioavailability is incomplete and, …

p38, a mitogen-activated protein kinase, is a major intracellular signaling molecule involved
in inflammation. To test the hypothesis that p38 mediates renal disease progression, we …

The aberrant activation of B-cells has been implicated in several types of cancers and
hematological disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, …

The effects of marijuana extract (ME) and ∆ 9 -tetrahydrocannabinol (THC) on corpus luteum
function were studied in the rhesus monkey by the use of in vivo and in vitro techniques. …

Although the synthetic version of the cardiac peptide human brain natriuretic peptide (hBNP)
has demonstrated beneficial cardiovascular effects in clinical studies, little is known about …

The role of endogenous opioid peptides (EOP)in the neuroendocrine control of primate
gonadotropin and PRLsecretion was studied in nonrestrained adult male rhesus monkeys.…