User profiles for Ragnhild Elisabeth Paulsen
Ragnhild PaulsenUniversity of Oslo Verified email at farmasi.uio.no Cited by 3798 |
Cracking the egg: potential of the developing chicken as a model system for nonclinical safety studies of pharmaceuticals
…, LPE Austdal, B Roald, JC Glover, RE Paulsen - … of Pharmacology and …, 2015 - ASPET
The advance of perinatal medicine has improved the survival of extremely premature babies,
thereby creating a new and heterogeneous patient group with limited information on …
thereby creating a new and heterogeneous patient group with limited information on …
[HTML][HTML] Chicken embryo as animal model to study drug distribution to the developing brain
…, JS Lumor, JM Andersen, RE Paulsen - … of pharmacological and …, 2021 - Elsevier
Introduction Rodent models are routinely used to assess the safety and developmental
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …
PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons
…, J Fuentes-Lazaro, S Verhaegen, RE Paulsen… - Toxicology and applied …, 2018 - Elsevier
Perfluoroalkyl acids (PFAAs) are persistent compounds used in many industrial as well as
consumer products. Despite restrictions, these compounds are found at measurable …
consumer products. Despite restrictions, these compounds are found at measurable …
[HTML][HTML] Paracetamol perturbs neuronal arborization and disrupts the cytoskeletal proteins SPTBN1 and TUBB3 in both human and chicken in vitro models
Epidemiological studies have linked long-term/high-dose usage of paracetamol (N-acetyl-para-aminophenol,
APAP) during pregnancy to adverse neuropsychiatric outcomes, primarily …
APAP) during pregnancy to adverse neuropsychiatric outcomes, primarily …
[HTML][HTML] Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure
Persistent organic pollutants (POPs) can reach the fetal brain and contribute to developmental
neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken …
neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken …
[HTML][HTML] Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro
…, G Østby, R Halsne, G Boge, RE Paulsen… - Environment …, 2021 - Elsevier
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl),
brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse …
brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse …
[HTML][HTML] Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of …
…, KE Zimmer, PA Fowler, RE Paulsen… - Environment …, 2022 - Elsevier
Prenatal exposure to persistent organic pollutants (POPs) is associated with neurodevelopmental
disorders. In the present study, we explored whether a human-relevant POP mixture …
disorders. In the present study, we explored whether a human-relevant POP mixture …
[HTML][HTML] Developmental neurotoxicity of acrylamide and its metabolite glycidamide in a human mixed culture of neurons and astrocytes undergoing differentiation in …
Neural stem cells (NSCs) derived from human induced pluripotent stem cells were used to
investigate effects of exposure to the food contaminant acrylamide (AA) and its main …
investigate effects of exposure to the food contaminant acrylamide (AA) and its main …
Opioid receptor-mediated changes in the NMDA receptor in developing rat and chicken
…, A Šulović, JM Andersen, RE Paulsen - International Journal of …, 2019 - Elsevier
The use of opioids during pregnancy has been associated with neurodevelopmental toxicity
in exposed children, leading to cognitive and behavioural deficits later in life. The N-methyl-…
in exposed children, leading to cognitive and behavioural deficits later in life. The N-methyl-…
[HTML][HTML] A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic …
…, KE Zimmer, E Ropstad, RE Paulsen - Reproductive …, 2021 - Elsevier
Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were
used to explore the effects on developmental neurotoxicity by a complex defined mixture of …
used to explore the effects on developmental neurotoxicity by a complex defined mixture of …