User profiles for Ragnhild Elisabeth Paulsen

Ragnhild Paulsen

University of Oslo
Verified email at farmasi.uio.no
Cited by 3798

Cracking the egg: potential of the developing chicken as a model system for nonclinical safety studies of pharmaceuticals

…, LPE Austdal, B Roald, JC Glover, RE Paulsen - … of Pharmacology and …, 2015 - ASPET
The advance of perinatal medicine has improved the survival of extremely premature babies,
thereby creating a new and heterogeneous patient group with limited information on …

[HTML][HTML] Chicken embryo as animal model to study drug distribution to the developing brain

…, JS Lumor, JM Andersen, RE Paulsen - … of pharmacological and …, 2021 - Elsevier
Introduction Rodent models are routinely used to assess the safety and developmental
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …

PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons

…, J Fuentes-Lazaro, S Verhaegen, RE Paulsen… - Toxicology and applied …, 2018 - Elsevier
Perfluoroalkyl acids (PFAAs) are persistent compounds used in many industrial as well as
consumer products. Despite restrictions, these compounds are found at measurable …

[HTML][HTML] Paracetamol perturbs neuronal arborization and disrupts the cytoskeletal proteins SPTBN1 and TUBB3 in both human and chicken in vitro models

…, N Houdaifi, D Zosen, F Haugen, RE Paulsen… - Toxicology and Applied …, 2022 - Elsevier
Epidemiological studies have linked long-term/high-dose usage of paracetamol (N-acetyl-para-aminophenol,
APAP) during pregnancy to adverse neuropsychiatric outcomes, primarily …

[HTML][HTML] Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure

…, LS Haug, O Myhre, KE Zimmer, RE Paulsen… - NeuroToxicology, 2022 - Elsevier
Persistent organic pollutants (POPs) can reach the fetal brain and contribute to developmental
neurotoxicity. To explore the distribution of POPs to the fetal brain, we exposed chicken …

[HTML][HTML] Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro

…, G Østby, R Halsne, G Boge, RE Paulsen… - Environment …, 2021 - Elsevier
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl),
brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse …

[HTML][HTML] Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of …

…, KE Zimmer, PA Fowler, RE Paulsen… - Environment …, 2022 - Elsevier
Prenatal exposure to persistent organic pollutants (POPs) is associated with neurodevelopmental
disorders. In the present study, we explored whether a human-relevant POP mixture …

[HTML][HTML] Developmental neurotoxicity of acrylamide and its metabolite glycidamide in a human mixed culture of neurons and astrocytes undergoing differentiation in …

AJ Lauvås, M Lislien, JA Holme, H Dirven, RE Paulsen… - Neurotoxicology, 2022 - Elsevier
Neural stem cells (NSCs) derived from human induced pluripotent stem cells were used to
investigate effects of exposure to the food contaminant acrylamide (AA) and its main …

Opioid receptor-mediated changes in the NMDA receptor in developing rat and chicken

…, A Šulović, JM Andersen, RE Paulsen - International Journal of …, 2019 - Elsevier
The use of opioids during pregnancy has been associated with neurodevelopmental toxicity
in exposed children, leading to cognitive and behavioural deficits later in life. The N-methyl-…

[HTML][HTML] A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic …

…, KE Zimmer, E Ropstad, RE Paulsen - Reproductive …, 2021 - Elsevier
Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were
used to explore the effects on developmental neurotoxicity by a complex defined mixture of …