Individual protein kinase C (PKC) isozymes have been implicated in many cellular responses
important in lung health and disease, including permeability, contraction, migration, …

Alcoholism, a worldwide disorder, is the cause of a variety of neurologic disorders. In this
article we discuss the cellular pathophysiology of ethanol addition and abuse as well as …

Neurogenesis in the dentate gyrus of adult rodents is regulated by NMDA receptors, adrenal
steroids, environmental stimuli, and seizures. To determine whether ischemia affects …

Ethanol’s effects on intracellular signaling pathways contribute to acute effects of ethanol as
well as to neuroadaptive responses to repeated ethanol exposure. In this chapter we review …

There is great interest in discovering new targets for pain therapy since current methods of
analgesia are often only partially successful. Although protein kinase C (PKC) enhances …

We have identified a mechanism, mediated by the ε isozyme of protein kinase C (PKCε) in
peripheral neurons, which may have a role in chronic inflammatory pain. Acute inflammation, …

The ubiquitous nature of protein phosphorylation makes it challenging to map kinase-substrate
relationships, which is a necessary step toward defining signaling network architecture. …

Several of the actions of ethanol are mediated by γ-aminobutyrate type A (GABA A) receptors.
Here we demonstrated that mutant mice lacking protein kinase C epsilon (PKCε) were …

Compulsive drinking despite serious adverse medical, social and economic consequences
is a characteristic of alcohol use disorders in humans. Although frontal cortical areas have …

Adenosine is an important mediator of ethanol intoxication. In vitro, ethanol stimulates adenosine
signaling by inhibiting the type 1 equilibrative nucleoside transporter (ENT1), whereas …