Low-dose aspirin in pregnancy

BM SIBAI, R MIRRO, CM CHESNEY… - Obstetrics & …, 1989 - journals.lww.com
In a prospective study, we evaluated the effects of low-dose aspirin on maternal and neonatal
plasma 6-keto-prostaglandin (PG) F1 [alpha] concentration, platelet aggregation, platelet …

Postischemic generation of superoxide anion by newborn pig brain

WM Armstead, R Mirro, DW Busija… - American Journal of …, 1988 - journals.physiology.org
Cerebral superoxide anion generation during reperfusion after total cerebral ischemia was
measured in newborn pigs. Superoxide dismutase (SOD)-inhibitable nitroblue tetrazolium (…

Cerebral superoxide anion generation during seizures in newborn pigs

WM Armstead, R Mirro, CW Leffler… - Journal of Cerebral …, 1989 - journals.sagepub.com
Cerebral superoxide anion generation during bicuculline-induced seizures was measured
in newborn pigs. Using two closed cranial windows inserted over the parietal cortices, …

Relationship between mean airway pressure, cardiac output, and organ blood flow with normal and decreased respiratory compliance

R Mirro, D Busija, R Green, C Leffler - The Journal of pediatrics, 1987 - Elsevier
We investigated the relation between blood flow and mean airway pressure in two groups of
anesthetized newborn piglets. The first group had normal respiratory compliance; the …

Polyethylene glycol superoxide dismutase and catalase attenuate increased blood-brain barrier permeability after ischemia in piglets.

WM Armstead, R Mirro, OP Thelin, M Shibata… - Stroke, 1992 - Am Heart Assoc
Transport of urea across the blood-brain barrier is increased during postischemic cerebral
reperfusion in the piglet. Ischemia/reperfusion also has been observed to increase apparent …

Permissive role of prostacyclin in cerebral vasodilation to hypercapnia in newborn pigs

CW Leffler, R Mirro, LJ Pharris… - American Journal of …, 1994 - journals.physiology.org
Hypercapnic cerebral vasodilation in piglets is accompanied by increased cerebral prostanoid
synthesis. Interventions that prevent the increased prostanoids also interfere with the …

Influence of endothelin on piglet cerebral microcirculation

WM Armstead, R Mirro, CW Leffler… - American Journal of …, 1989 - journals.physiology.org
The purpose of this study was to determine responses of the newborn pig cerebral microcirculation
to endothelin. Pial arterioles were observed directly using a closed cranial window in …

Increased airway leukotriene levels in infants with severe bronchopulmonary dysplasia

R Mirro, W Armstead, C Leffler - American Journal of Diseases of …, 1990 - jamanetwork.com
• The sulphidopeptide leukotrienes (C 4 , D 4 , and E 4 ) are potent airway constrictors that
have been detected in the airways of infants with pulmonary hypertension and viral infections. …

Effects of ischemia on brain blood flow and oxygen consumption of newborn pigs

CW Leffler, DW Busija, R Mirro… - American Journal …, 1989 - journals.physiology.org
Brain circulation after 20 min of total brain ischemia was examined in unanesthetized newborn
pigs. Except in the cerebrum, reactive hyperemia was observed throughout the brain, …

Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs

CW Leffler, R Mirro, DR Shanklin… - American Journal …, 1994 - journals.physiology.org
Cerebral vasodilation in response to hypercapnia involves prostanoids in newborn pigs. This
study examines the hypothesis that endothelial injury in vivo inhibits cerebral vasodilation …