This review discusses the role of three mediators, synthesized by vascular endothelial cells,
that help to keep the surface of the normal endothelium nonthrombogenic. The first is …

Flavonoids are benzo-gamma-pyrone derivatives of plant origin. They possess wide spectrum
of biological activity. From the therapeutical point of view the most important are their …

… Gryglewski RJ, Szczeklik A, Ni¿ankowski R: Antiplatelet action of intravenous infusion …
Szczeklik A, Ni¿ankowski R, Skawiñski S, Szczeklik J, G³uszko P, Gryglewski RJ: Successful …

Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG 2 or PGH
2 ) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 …

… Based on a comparison of their restriction maps with the map of a related gene which
has been sequenced (R. Thiebe, unpublished), the V, I genes are non-processed genes or …

Seven flavonoids and three non-flavonoid antioxidants, ie butylated hydroxy anisole,
chlorpromazine and BW 755 C, were studied as potential scavengers of oxygen free radicals. …

Fresh arterial tissue generates an unstable substance (prostaglandin X) which relaxes vascular
smooth muscle and potently inhibits platelet aggregation. The release of prostaglandin (…

… The number of experiments (N) was adjusted so as to reach the regression coefficient r >
0.8; b was the slope of the regression line. The potency of antiaggregatory and disaggregatory …

Prostaglandin (PG) endoperoxides (PGG 2 and PGH 2 ) contract arterial smooth muscle and
cause platelet aggregation. Microsomes from pig aorta, pig mesenteric arteries, rabbit aorta …

… complex to the IC50 for inhibiting prostaglandin synthetase (Q ratio in table II) was taken
as the index of the inhibitory action of a drug on prostaglandin generation in vivo (Gryglewski, …