Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity

…, D Tulshian, H Vaccaro, RW Watkins… - Journal of Medicinal …, 1997 - ACS Publications
Tetracyclic guanines have been shown to be potent and selective inhibitors of the cGMP-hydrolyzing
enzymes PDE1 and PDE5. In general, these compounds are inactive or only …

The effect of microscopic core heterogeneity on miscible flood residual oil saturation

AP Spence Jr, RW Watkins - SPE Annual Technical Conference and …, 1980 - onepetro.org
Much effort has been devoted to understanding the mechanisms responsible for the variation
of CO 2 flood residual oil saturations found both in the laboratory and in the field-Some of …

The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a …

…, KB Alton, RE Burrier, RW Watkins - Metabolism-Clinical …, 2001 - metabolismjournal.com
Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which
cause significant decreases in plasma cholesterol levels in cholesterol-fed animals and in …

A total internal‐reflection technique for the examination of protein adsorption

RW Watkins, CR Robertson - Journal of Biomedical Materials …, 1977 - Wiley Online Library
A Total internal‐reflection fluorescence (TIRF) technique for examining protein adsorption at
solid‐liquid interfaces is described. For the representative case of adsorption of bovine γ‐…

SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals

…, DB Lowe, AJ Pond, RP Tedesco, RW Watkins… - European journal of …, 2001 - Elsevier
The present studies were designed to assess whether the novel muscarinic M 2 receptor
antagonist 4-cyclohexyl-α-[4[[4-methoxyphenyl]sulphinyl]-phenyl]-1-piperazineacetonitrile (…

Boosting silica levels in wheat leaves reduces grazing by rabbits

JV Cotterill, RW Watkins, CB Brennon… - Pest Management …, 2007 - Wiley Online Library
Systemic application of sodium silicate can significantly enhance the levels of leaf silica in
winter wheat (Triticum aestivum L. cv. Mercia), suggesting that this material could reduce the …

Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor

S Vemulapalli, RW Watkins, M Chintala… - Journal of …, 1996 - journals.lww.com
SCH 51866 is a potent and selective PDE1 and PDE5 inhibitor. The antiplatelet, antiproliferative,
and hemodynamic effects of SCH 51866 were compared with those of E4021, a highly …

SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone …

…, S Vemulapalli, B Pitts, CJ Foster, RW Watkins… - … of Pharmacology and …, 1989 - ASPET
SCH 39370 (N-[N-[1-(S)-carboxyl-3-phenylpropyl]-(S)-phenyl-alanyl]-(S)-isoserin e) is a
potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney (IC50 = …

Learned food aversion with and without an odour cue for protecting untreated baits from wild mammal foraging

SE Baker, PJ Johnson, D Slater, RW Watkins… - Applied Animal …, 2007 - Elsevier
Lethal methods of controlling wildlife foraging damage may present difficulties regarding
conservation, ethics, welfare, and efficacy, providing an imperative to develop non-lethal …

Chemical products from temperate forest tree species—Developing strategies for exploitation

DB Turley, Q Chaudhry, RW Watkins, JH Clark… - Industrial Crops and …, 2006 - Elsevier
Forest trees are integral to the landscape and rural economy. Unfortunately, the economic
returns from timber production have declined significantly across Europe. Only 25% of felled …