Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model.
EM Kudlacz, RW Knippenberg, DE Logan… - … of Pharmacology and …, 1996 - ASPET
MDL 105,212 has been identified as a potent, nonpeptide NK-1 and NK-2 receptor antagonist
that inhibits effects of substance P and neurokinin A in vitro and in vivo (Kudlacz et al., …
that inhibits effects of substance P and neurokinin A in vitro and in vivo (Kudlacz et al., …
In vitro and in vivo characterization of MDL 105,212 A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
EM Kudlacz, SA Shatzer, RW Knippenberg… - … of Pharmacology and …, 1996 - ASPET
We have identified and characterized a novel, potent, nonselective tachykinin receptor
antagonist, MDL 105,212A [(R)-1-[2-[3-(3,4- dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)-…
antagonist, MDL 105,212A [(R)-1-[2-[3-(3,4- dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)-…
Nonsteroidal anti-inflammatory drugs correct the bactericidal defect of polymorphonuclear leukocytes in a guinea pig model of thermal injury
AB Bjornson, RW Knippenberg… - Journal of Infectious …, 1988 - academic.oup.com
We conducted studies to determine the effects of parenteral therapy with indomethacin,
ibuprofen, and piroxicam on key immunologic and hematologic alterations induced by thermal …
ibuprofen, and piroxicam on key immunologic and hematologic alterations induced by thermal …
Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors
…, EM Kudlacz, TB Le, RW Knippenberg… - Bioorganic & Medicinal …, 1996 - Elsevier
We have synthesized and identified MDL 105,212, a non-peptide tachykinin receptor
antagonist that has high affinity for human NK 1 (IC 50 =3.11 nM) and NK 2 (IC 50 =8.40 nM) …
antagonist that has high affinity for human NK 1 (IC 50 =3.11 nM) and NK 2 (IC 50 =8.40 nM) …
Temporal relationships among immunologic alterations in a guinea pig model of thermal injury
…, HS Bjornson, RW Knippenberg… - Journal of Infectious …, 1986 - academic.oup.com
Temporal relationships among various humoral and cellular alterations of host defense
mechanisms were investigated in a guinea pig model of thermal injury during three weeks after …
mechanisms were investigated in a guinea pig model of thermal injury during three weeks after …
Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl) piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity
…, EM Kudlacz, SA Shatzer, RW Knippenberg… - Bioorganic & Medicinal …, 1997 - Elsevier
A series of 4-(1H-benzimidazole-2-carbonyl) piperidines with dual histamine H1/tachykinin
NK1 receptor antagonist activity has been prepared. Factors affecting receptor binding …
NK1 receptor antagonist activity has been prepared. Factors affecting receptor binding …
In vitro and in vivo effects of tachykinins on immune cell function in guinea pig airways
EM Kudlacz, RW Knippenberg - Journal of neuroimmunology, 1994 - Elsevier
The effects of sensory neuropeptides substance P (SP) and neurokinin A (NKA) on immune
cell recruitment and macrophage activation were determined. Guinea pigs exposed to …
cell recruitment and macrophage activation were determined. Guinea pigs exposed to …
Bactericidal defect of neutrophils in a guinea pig model of thermal injury is related to elevation of intracellular cyclic-3', 5'-adenosine monophosphate.
AB Bjornson, RW Knippenberg… - Journal of immunology …, 1989 - journals.aai.org
PG of the E series inhibit major effector functions of polymorphonuclear leukocytes (PMN)
by elevating intracellular cAMP. The present study investigated the involvement of this …
by elevating intracellular cAMP. The present study investigated the involvement of this …
Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists
…, F Boyer, L Bratton, RS Gross, RW Knippenberg… - Bioorganic & Medicinal …, 1997 - Elsevier
We recently described the synthesis and characterization of MDL 105,212, a non peptide
tachykinin antagonist with high affinity for NK 1 and NK 2 receptors. Here we report the …
tachykinin antagonist with high affinity for NK 1 and NK 2 receptors. Here we report the …
Circulating factors contribute to elevation of intracellular cyclic‐3′, 5′‐adenosine monophosphate and depression of superoxide anion production in …
…, SD Somers, RW Knippenberg… - Journal of leukocyte …, 1992 - Wiley Online Library
We have previously demonstrated that bactericidal activity and superoxide anion (O 2 − )
production are depressed concomitantly in polymorphonuclear leukocytes (PMNs) following …
production are depressed concomitantly in polymorphonuclear leukocytes (PMNs) following …