We have examined the effect of intrajugular administration of platelet activating factor (PAF-C
16 ) on vascular permeability in the guinea pig. To examine the loss of selective …

Platelet activating factor (paf) given intravenously produces systemic hypotension in the rat.
Similar effects can be induced using endotoxin or heat-aggregated IgG challenges, which …

Balloon catheter damage of the rat carotid artery endothelium results in an extensive and
reproducible neointimal lesion composed of smooth muscle cells and connective matrix. The …

Terbinafine [(E)-N(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthale nemethanamine],
an antimycotic agent that inhibits fungal squalene epoxidase activity, was examined for its …

SDZ 64-412 is a trimethoxyphenylethylphenyl imidazo[2,1-a] isoquinoline molecule that
displays marked in vitro inhibition of platelet activating factor (PAF)-induced human platelet …

PAF-induced aggregation and dense granule release (ATP release) were investigated in
human, primate, guinea pig, rabbit and rat platelet-rich plasma (PRP). Guinea pig PRP was …

Platelet-activating factor (PAF) is a naturally occurring lipid that is reported to induce vessel
hyperpermeability leading to loss of protein-rich plasma (extravasation). We have quantitated …

Intravenous administration of platelet-activating factor (PAF) produces dose-dependent
hypotension in several species. We have evaluated a recently developed PAF antagonist, SRI 63…

Allergen challenge by aerosol in sensitized guinea-pigs elicited non-specific airway
hyperreactivity assessed by reactivity to iv histamine or acetylcholine. Airway hyperreactivity to …

We have evaluated several effects of intravenous administration of synthetic platelet-activating
factor (PAF) in the non-human primate Cebus apella. Parameters measured were …