Enhanced degradation of EGF receptors by a sorting nexin, SNX1
RC Kurten, DL Cadena, GN Gill - Science, 1996 - science.org
The vectorial movement of proteins requires specific recognition by components of the
vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell …
vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell …
Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes
AB Reid, RC Kurten, SS McCullough, RW Brock… - … of Pharmacology and …, 2005 - ASPET
Freshly isolated mouse hepatocytes were used to determine the role of mitochondrial
permeability transition (MPT) in acetaminophen (APAP) toxicity. Incubation of APAP (1 mM) with …
permeability transition (MPT) in acetaminophen (APAP) toxicity. Incubation of APAP (1 mM) with …
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
…, F Chouiali, TA Doherty, RC Kurten… - Proceedings of the …, 2016 - National Acad Sciences
Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …
Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
…, M Aquino, A Doshi, HH Walford, RC Kurten… - Journal of Allergy and …, 2015 - jacionline.org
To identify esophageal ILC2s, we obtained biopsies from patients undergoing endoscopy
for routine care (University of California at San Diego institutional review board approved …
for routine care (University of California at San Diego institutional review board approved …
Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
…, SK Hussain, UM Sharma, RC Kurten… - Cellular …, 2013 - Wiley Online Library
The intracellular bacterial pathogen C oxiella burnetii is a category B select agent that causes
human Q fever. In vivo, C . burnetii targets alveolar macrophages wherein the pathogen …
human Q fever. In vivo, C . burnetii targets alveolar macrophages wherein the pathogen …
TAS2R activation promotes airway smooth muscle relaxation despite β2-adrenergic receptor tachyphylaxis
…, K Ahn, DY Lee, RC Kurten… - … of Physiology-Lung …, 2012 - journals.physiology.org
Recently, bitter taste receptors (TAS2Rs) were found in the lung and act to relax airway
smooth muscle (ASM) via intracellular Ca 2+ concentration signaling generated from restricted …
smooth muscle (ASM) via intracellular Ca 2+ concentration signaling generated from restricted …
Coxiella burnetii type IV secretion-dependent recruitment of macrophage autophagosomes
CG Winchell, JG Graham, RC Kurten… - Infection and …, 2014 - Am Soc Microbiol
Coxiella burnetii is an intracellular Gram-negative bacterium that causes human Q fever, a
flu-like disease that can progress to chronic, life-threatening endocarditis. In humans, C. …
flu-like disease that can progress to chronic, life-threatening endocarditis. In humans, C. …
β2 integrins rather than β1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung
…, CY Vuong, M Miller, S Das, RC Kurten… - Journal of Allergy and …, 2018 - Elsevier
Background Group 2 innate lymphoid cells (ILC2s) expand in the lungs of mice during type
2 inflammation induced by the fungal allergen Alternaria alternata. The increase in ILC2 …
2 inflammation induced by the fungal allergen Alternaria alternata. The increase in ILC2 …
Sorting motifs in receptor trafficking
RC Kurten - Advanced drug delivery reviews, 2003 - Elsevier
A variety of receptors have been analyzed in sufficient detail to identify sorting motifs. Initial
studies focused on the identification of sequences in the cytoplasmic tails of the LDL and …
studies focused on the identification of sequences in the cytoplasmic tails of the LDL and …
Increased production of LIGHT by T cells in eosinophilic esophagitis promotes differentiation of esophageal fibroblasts toward an inflammatory phenotype
MC Manresa, AWT Chiang, RC Kurten, R Dohil… - Gastroenterology, 2020 - Elsevier
Background & Aims Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis. …
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis. …