Prions are the transmissible pathogenic agents responsible for diseases such as scrapie
and bovine spongiform encephalopathy. In the favoured model of prion replication, direct …

Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC), a protein
assembly that plays a critical role in a variety of muscular dystrophies. In order to better …

Of the vertebrate senses, touch is the least understood at the molecular level. The ion channels
that form the core of the mechanosensory complex and confer touch sensitivity remain …

… Williamson, RA et al. Dystroglycan is essential for early embryonic development: disruption
of … We thank R. Fässler for his gifts of plasmids for construction of the floxed allele. Technical …

In earthquake zones pipeline crossings of major active faults are often unavoidable, and
movements of these faults can have serious consequences for the pipeline. The ability of a …

Neuronal death is a prominent, but poorly understood, pathological hallmark of prion
disease. Notably, in the absence of the cellular prion protein (PrP C ), the disease-associated …

The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain–containing
leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor …

The scrapie prion protein (PrP Sc ) is formed from the cellular isoform (PrP C ) by a post-translational
process that involves a profound conformational change. Linear epitopes for …

The proteins ESAT-6 and CFP-10 have been shown to be secreted by Mycobacterium
tuberculosis and Mycobacterium bovis cells, to be potent T-cell antigens, and to have a clear but …

… The rat pancreatic elastase promoter-enhancer was obtained from R. MacDonald (Kruse
et al., 1988) and the +8 to -205 Sal-Barn fragment subcloned into the polylinker of pUC19. A …