User profiles for Róbert Gáspár

Robert Gaspar

Dept. of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School …
Verified email at med.u-szeged.hu
Cited by 1859

[HTML][HTML] Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes

…, S Grossmann, A Klukovits, J Verli, R Gáspár… - Journal of biological …, 2011 - ASBMB
A-kinase anchoring proteins (AKAPs) tether protein kinase A (PKA) and other signaling
proteins to defined intracellular sites, thereby establishing compartmentalized cAMP signaling. …

Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin

…, L Kemény, A Sztojkov-Ivanov, R Gáspár… - International journal …, 2016 - Taylor & Francis
An ibuprofen-loaded nanostructured lipid carrier (IBU-NLC) was developed for enhanced skin
penetration to improve the treatment of osteoarthritis and other musculoskeletal diseases. …

Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: preparation, characterization, and in vivo evaluation

…, F Tömösi, T Janáky, A Kovács, R Gáspár… - International journal of …, 2020 - Elsevier
The unique requirements of poorly water-soluble drug delivery have driven a great deal of
research into new formulations and routes of administration. This study investigates the use of …

[HTML][HTML] Calcium channel blockers as tocolytics: principles of their actions, adverse effects and therapeutic combinations

R Gáspár, J Hajagos-Tóth - Pharmaceuticals, 2013 - mdpi.com
Dihydropyridine Ca 2+ channel blockers (CCBs) are widely accepted in the treatment of
premature labour. Their mechanism of action in tocolysis involves the blockade of L-type Ca 2+ …

[HTML][HTML] Development of meloxicam-human serum albumin nanoparticles for nose-to-brain delivery via application of a quality by design approach

G Katona, GT Balogh, G Dargó, R Gáspár, Á Márki… - Pharmaceutics, 2020 - mdpi.com
The aim of this study was to optimize the formulation of meloxicam (MEL)-containing human
serum albumin (HSA) nanoparticles for nose-to-brain via a quality by design (QbD) approach…

In vitro and in vivo characterization of meloxicam nanoparticles designed for nasal administration

L Kürti, R Gáspár, Á Márki, E Kápolna, A Bocsik… - European Journal of …, 2013 - Elsevier
The nasal pathway represents a non-invasive route for delivery of drugs to the systemic
circulation. Nanonization of poorly soluble drugs offers a possibility to increase dissolution …

[HTML][HTML] Aquaporins during pregnancy: their function and significance

E Ducza, A Csányi, R Gáspár - International journal of molecular sciences, 2017 - mdpi.com
Water is the major component of cells and tissues, and the movement of water across the
cell membrane is a fundamental property of life. Until the discovery of the first water channel, …

Study of sodium hyaluronate-based intranasal formulations containing micro-or nanosized meloxicam particles

…, P Sipos, M Budai-Szűcs, E Csányi, R Gáspár… - International journal of …, 2015 - Elsevier
This article reports on the micro- and nanonization of meloxicam (MEL) with the aim of
developing pre-dispersions as intermediates for the design of intranasal formulations. As a new …

Phenotypic plasticity of melanocytes derived from human adult skin

…, BT Papp, M Manczinger, R Gáspár… - Pigment Cell & …, 2022 - Wiley Online Library
We previously described a novel in vitro culture technique for dedifferentiated human adult
skin melanocytes. Melanocytes cultured in a defined, cholera toxin and PMA free medium …

Effect of solubility enhancement on nasal absorption of meloxicam

…, K Takács-Novák, E Csányi, R Gáspár… - European Journal of …, 2016 - Elsevier
Besides the opioids the standard management of the World Health Organization suggests
NSAIDs (non-steroidal anti-inflammatory drugs) alone or in combination to enhance analgesia …