Background/Aims: Non-alcoholic steatohepatitis (NASH) is increasingly recognized, and its
pathogenesis is believed to involve increased oxidative stress. Elevated levels of serum …

Heme oxygenase (HO) catalyzes the conversion of heme to biliverdin with the release of
iron and carbon monoxide. HO‐1 is highly inducible by a large number of physical and …

In some, but not all countries, porphyria cutanea tarda (PCT) has been associated with chronic
infection with the hepatitis C virus (HCV). Recently, PCT has also been associated with …

Background & Aims: Heme oxygenase-1 (HO-1) is an antioxidant defense and key
cytoprotective enzyme, which is repressed by Bach1. Micro-RNA-122 (miR-122) is specifically …

Heavy iron overload, in both primary and secondary hemochromatosis, may cause fibrosis
of parenchymal organs, especially the liver. The toxicity of iron is believed to involve …

Induction of expression of heme oxygenase-1 (HO-1) has been studied in primary cultures of
chick embryo liver cells and in the LMH line of avian hepatoma cells. Cells were transiently …

Background . There is growing evidence that mildly increased amounts of iron in the liver
can increase hepatic injury, particularly if combined with other hepatotoxic factors, such as …

Camphor, α-pinene (the major component of turpentine), and thujone (a constituent in the
liqueur called absinthe) produced an increase in porphyrin production in primary cultures of …

Background & Aims Iron may influence severity and progression of non-hemochromatotic
liver diseases. Our aim was to assess the relationship of iron and HFE genetic variations to …

Background & Aims: Iron overload may cause or contribute to hepatic injury and fibrosis.
Mutations in the HFE gene may influence development or progression of chronic liver disease …