Expression and pharmacological characterization of the human D3 dopamine receptor.
SB Freedman, S Patel, R Marwood, F Emms… - … of Pharmacology and …, 1994 - ASPET
Binding of dopamine receptor ligands to human D2 and D3 receptors was characterized in
Chinese hamster ovary (CHO) cells using the dopamine D2 receptor antagonist [125I] …
Chinese hamster ovary (CHO) cells using the dopamine D2 receptor antagonist [125I] …
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor
…, F Emms, AE Fletcher, M Knowles, R Marwood… - … of Pharmacology and …, 1997 - ASPET
L-745,870,(3-{[4-(4-chlorophenyl)piperazin-1-yl]methyl}-1Hpyrollo[2,3-b] pyridine, was
identified as a selective dopamine D4 receptor antagonist with excellent oral bioavailability and …
identified as a selective dopamine D4 receptor antagonist with excellent oral bioavailability and …
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists
…, TJ Sparey, S Patel, R Marwood… - Journal of medicinal …, 2001 - ACS Publications
The development of very high affinity, selective, and bioavailable h5-HT 2A receptor antagonists
is described. By investigation of the optimal position for the basic nitrogen in a series of …
is described. By investigation of the optimal position for the basic nitrogen in a series of …
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl) piperidin-4-yl) isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors
…, I Collins, R Baker, F Emms, R Marwood… - Journal of medicinal …, 1996 - ACS Publications
Schizophrenia is a mental illness for which there is still a great need for novel drug therapy.
Classical neuroleptics, which are presumed to act by antagonism of dopamine D2 receptors, …
Classical neuroleptics, which are presumed to act by antagonism of dopamine D2 receptors, …
[HTML][HTML] KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe
…, R Marwood, J Watson, J Tart, R Overman… - Nature …, 2019 - nature.com
Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions
that interact with signalling effector proteins. Here, we report designed ankyrin repeat …
that interact with signalling effector proteins. Here, we report designed ankyrin repeat …
[HTML][HTML] Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
…, N Bery, R Marwood, J Tart, R Overman… - Nature …, 2017 - nature.com
Ras mutations are the oncogenic drivers of many human cancers and yet there are still no
approved Ras-targeted cancer therapies. Inhibition of Ras nucleotide exchange is a …
approved Ras-targeted cancer therapies. Inhibition of Ras nucleotide exchange is a …
Nosocomial transmission of group B streptococci.
…, MJ Hastings, AJ Clare, B Bloxham, R Marwood… - Br Med J (Clin Res …, 1981 - bmj.com
The acquisition of group B streptococci by babies in a special-care baby unit and two postnatal
wards was investigated over a six-month period using serology and phage typing. Sixty-…
wards was investigated over a six-month period using serology and phage typing. Sixty-…
The effect of intrapartum chemoprophylaxis on the vertical transmission of group B streptococci
…, B BLOXHAM, RPA Rivers, R Marwood - … Journal of Obstetrics …, 1983 - Wiley Online Library
Intrapartum chemoprophylaxis with benzylpenicillin or erythromycin significantly reduced
the rate of transmission of group B streptococci (GBS) from mothers colonized during …
the rate of transmission of group B streptococci (GBS) from mothers colonized during …
2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor
…, SG Michie, JG Neduvelil, S Patel, R Marwood… - Bioorganic & medicinal …, 2000 - Elsevier
A series of 2-aryl tryptamines have been identified as high-affinity h5-HT 2A antagonists.
Structure–activity relationship studies have shown that h5-HT 2A affinity can be attained via …
Structure–activity relationship studies have shown that h5-HT 2A affinity can be attained via …
The effect of foetal bovine serum supplementation upon the lactate dehydrogenase cytotoxicity assay: Important considerations for in vitro toxicity analysis
MG Thomas, RM Marwood, AE Parsons, RB Parsons - Toxicology in vitro, 2015 - Elsevier
… free for all, n = 3), which linear regression analysis demonstrated to be dose-dependent (R
2 … demonstrated that the reduction in rDR was linear with increasing FBS concentration (R 2 …
2 … demonstrated that the reduction in rDR was linear with increasing FBS concentration (R 2 …