Relationship of guanabenz concentrations in brain and plasma to antihypertensive effect in the spontaneously hypertensive rat.
RH Meacham, HW Ruelius, CJ Kick, JR Peters… - … of Pharmacology and …, 1980 - ASPET
The antihypertensive agent guanabenz (E-2,6-dichlorobenzylidene aminoguanidine acetate.
Wy-8678) was administered iv in single doses of 10, 32 and 100 microgram/kg to groups of …
Wy-8678) was administered iv in single doses of 10, 32 and 100 microgram/kg to groups of …
Disposition of 14C‐guanabenz in patients with essential hypertension*
RH Meacham, M Emmett… - Clinical …, 1980 - Wiley Online Library
Capsules containing either 16 or 32 mg of 14 C‐guanabenz were given to 8 hypertensive
patients. Maximum concentrations of guanabenz in plasma (1.2 to 5.2 ng/ml) were reached at …
patients. Maximum concentrations of guanabenz in plasma (1.2 to 5.2 ng/ml) were reached at …
[PDF][PDF] Pharmacokinetic disposition of guanabenz in the rhesus monkey.
RH Meacham, ST Chiang, CJ Kick… - Drug Metabolism and …, 1981 - Citeseer
… acetate, Wy-8678) in rhesus monkeys given 14C-labeled and … of guanabenz in man and
the rhesus monkey indicate that the … was assessed in the rhesus monkey after iv and ig’doses. …
the rhesus monkey indicate that the … was assessed in the rhesus monkey after iv and ig’doses. …
Additional Routes in the Metabolism of Nicotine to 3-Pyridylacetate: THE METABOLISM OF DIHYDROMETANICOTINE
RH Meacham, ER Bowman, H McKennis - Journal of Biological Chemistry, 1972 - ASBMB
The metabolism of dihydrometanicotine was investigated in the rat and dog. In preliminary
studies, dihydrometanicotine difumarate was administered to rats. The R f values and …
studies, dihydrometanicotine difumarate was administered to rats. The R f values and …
Inhibition of ciramadol glucuronidation by benzodiazepines.
RH Meacham, SF Sisenwine, AL Liu, CJ Kick… - Drug metabolism and …, 1986 - ASPET
Studies on the inhibition of ciramadol glucuronidation by benzodiazepines were performed
in vitro and in vivo. Ciramadol glucuronidation was slower (Vmax, 1.56 vs. 5.40 nmol/min/mg …
in vitro and in vivo. Ciramadol glucuronidation was slower (Vmax, 1.56 vs. 5.40 nmol/min/mg …
Method for separation and determination of lactone and hydroxy acid forms of a new HMG CoA reductase inhibitor (RG 12561) in plasma
…, LS Storbeck, D Wells, RH Meacham Jr - … of Chromatography B …, 1991 - Elsevier
The new drug RG 12561 (I) is a lactone that is undergoing clinical evaluation for its cholesterol
lowering effect based on potent HMG CoA reductase inhibitory activity displayed by its …
lowering effect based on potent HMG CoA reductase inhibitory activity displayed by its …
[CITATION][C] Prinoxodan (RG W‐2938)
JA Barrett, RH Meacham Jr, MF Kelley… - Cardiovascular Drug …, 1990 - Wiley Online Library
Heart failure is the inability of the heart to pump adequate amounts of blood to meet the body’s
instantaneous metabolic demands (9). This results from progressive organic damage to …
instantaneous metabolic demands (9). This results from progressive organic damage to …
Biotransformation of/sup 14/C-lidamidine in the rat, Cynomolgus monkey and man
…, PL Berger, MP Kullberg, RH Meacham - Fed. Proc., Fed. Am. Soc …, 1986 - osti.gov
Lidamidine (L) (1-(2,6-dimethylphenyl)-3-methyl-amidinourea) is a novel antidiarrheal agent
in animals and man. Studies with /sup 14/C-(L) in rats and monkeys have shown that the …
in animals and man. Studies with /sup 14/C-(L) in rats and monkeys have shown that the …
The effects of coelomic fluid and isotonic homogenates of the freshwater Bryozoan Lophopodella carteri on fish tissue
RH Meacham - 1967 - scholarship.richmond.edu
A study was made to determine if fish tissue was poisoned by the coelomic fluid extracted from
the common coelomic cavity of colonies of the freshwater bryozoan, Lophopodella carteri (…
the common coelomic cavity of colonies of the freshwater bryozoan, Lophopodella carteri (…
Solenoid-operated swing-check valve
PD Quattrone, RH Meacham - 1972 - ntrs.nasa.gov
Modification of spring-loaded swing-check valve for solenoid operation provides low-
vacuum swing-check valve which can be operated remotely.
vacuum swing-check valve which can be operated remotely.