SCH391 66[(-)-trans-6, 7, 7a, 8, 9, 1 3b-hexahydro-3-chloro-2-hydN-methy1-5H-benzo [dJnaptho-2,
1-bJazeplne] is a benzonaphthazepine that has been evaluated as a selective Dl …

Objectives Dysregulation of dopaminergic signaling has been hypothesized to underlie the
motor and phonic tics in Tourette syndrome (TS). The objective of this trial was to evaluate …

Background: Dopamine D2 receptor antagonists used to treat Tourette syndrome may have
inadequate responses or intolerable side effects. We present results of a 4‐week randomized…

… This finding is consistent with the observation3 that receptor affinity in the 1-phenyl-líí-3-benzazepine
series is associated specifically with the R enantiomers. The absence of a …

The present study assessed the role of dopamine D1 and D2 receptors in the production of
an extrapyramidal syndrome(EPS) in Cebus ape/la monkeys. Previous studies have shown …

The following experiments evaluated the effects of warm- or cold-water swim stress on tail-flick
latencies (TFL) in mice. To first determine the appropriete control group, the TFL's of dry-vs…

… The affinity of SCH 23390 for the 5HT-2 receptor was 26 times greater than that of SCH
23388, while SCH 23389 was only 5 times more potent than SCH 23391 (Table 2). Similar …

… as it also blocks ACE (Chipkin et at., 1982d, … (Chipkin, 1982c). This is not the same as
the peak effect … C Data are from Chipkin et a!. (1983a). …

… The kinetics of the interaction between [3H]SCH 39 166 and the D1 receptor were studied
by determining the association and dissociation of the radioligand-receptor complex. These …

… In the first set of studies, 19 days of repeated treatment with either SCH 23390 or haloperidol
was used to selectively up-regulate D1 and D2 binding sites, respectively. In the second set …