Background— Endocannabinoids are novel lipid mediators with hypotensive and
cardiodepressor activity. Here, we examined the possible role of the endocannabinergic system in …

The cannabinoid analog abnormal cannabidiol [abn-cbd; (−)-4-(3–3,4-trans-p-menthadien-[1,8]-yl)-olivetol]
does not bind to CB 1 or CB 2 receptors, yet it acts as a full agonist in …

The present study tested two hypotheses: (1) that a receptor for extracellular Ca 2+ (Ca 2+
receptor [CaR]) is located in the perivascular sensory nerve system and (2) that activation of …

The effect of several regulators of whole animal Ca 2+ homeostasis on 45 Ca uptake by
primary cultures of aortic myocytes isolated from spontaneously hypertensive (SHR) and …

We tested the hypothesis that an endogenous cannabinoid (CB) receptor agonist, such as N-arachidonylethanolamine
(anandamide), is the transmitter that mediates perivascular …

The perivascular sensory nerve (PvN) Ca 2+ -sensing receptor (CaR) is implicated in Ca 2+
-induced relaxation of isolated, phenylephrine (PE)-contracted mesenteric arteries, which …

… In recent studies of arterial segments mounted on 14-μm gold wires, we have found EC 50
values for Ca 2+ of 1.45±0.02 mmol/L (RD Bukoski, 2001, unpublished observations), which …

1 We recently showed that perivascular sensory nerves of mesenteric branch arteries
express a receptor for extracellular Ca 2+ (CaR), and reported data indicating that this CaR …

… AndriantsitohainaR, Stoclet JC, Bukoski RD: Role of endothelium on the effects of neuropeptide
Y in mesenteric resistance arteries of spontaneously hypertensive and Wistar-Kyoto nor…

… Address correspondence and reprint requests to Richard Bukoski, PhD, Division of …
Young E, Bukoski RD, McCarron DA: Calcium metabo lism in experimental hypertension. …