Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation

QS Zhang, Y Heng, YH Yuan, NH Chen - Toxicology letters, 2017 - Elsevier
Parkinson’s disease (PD) is characterized by α-synuclein accumulation, dopaminergic neuron
loss and inflammation. α-Synuclein can be secreted by neurons and activate microglia to …

[HTML][HTML] Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease

Q Zhang, Y Heng, Z Mou, J Huang, Y Yuan… - Acta pharmacologica …, 2017 - nature.com
… Yu-he YUAN, Nai-hong CHEN, and Qiu-shuang ZHANG designed the study. Qiu-shuang
ZHANG performed the experiments and did the data analysis. Yang HENG, Zheng MOU, and …

Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein …

Y Heng, QS Zhang, Z Mu, JF Hu, YH Yuan, NH Chen - Toxicology Letters, 2016 - Elsevier
Parkinson’s disease (PD) is pathologically characterized by the progressive loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of …

NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model

L Wen, QS Zhang, Y Heng, Y Chen, S Wang, YH Yuan… - Toxicology letters, 2018 - Elsevier
Ample evidence shows that Parkinson’s disease (PD) is more than simply a central nervous
system (CNS) disorder: the immune system appears to participate in PD pathogenesis. …

NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP

Y Chen, Q Zhang, Q Shao, S Wang, Y Yuan… - Acta Pharmacologica …, 2019 - nature.com
Olfactory bulb, as one of sensory organs opening to the outside, is susceptible to toxic
environment and easy to deteriorate. Recent studies in Parkinson’s disease (PD) patients and 1-…

A Novel Bibenzyl Compound (20C) Protects Mice from 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine/Probenecid Toxicity by Regulating the α-Synuclein–Related …

QS Zhang, Y Heng, Y Chen, P Luo, L Wen… - … of Pharmacology and …, 2017 - ASPET
The novel bibenzyl compound 2-[4-hydroxy-3-(4- hydroxyphenyl) benzyl]-4-(4- hydroxyphenyl)
phenol (20C) plays a neuroprotective role in vitro, but its effects in vivo have not yet been …

Clinical, demographic and psychological characteristics of infertile male smokers in Northeast China

M Zhang, QS Zhang, HS Zheng… - Journal of …, 2016 - journals.sagepub.com
Objectives To investigate clinical, demographic and psychological characteristics of infertile
male smokers in northeast China. Methods Serum and semen samples were collected from …

Maillard reaction process optimization of wheat germ protein hydrolysate and analysis of volatile flavor compounds.

JM Chen, SR Yang, QS Zhang, DX Yan, JH Huang… - 2022 - cabidigitallibrary.org
Objective: To optimize the process conditions of Maillard reaction (MR) of wheat germ
protein hydrolysate (WGH), and analyze the volatile flavor compounds of Maillard reaction …

Effect of Cold Storage of Tenebrio molitor Pupae on the Breeding of Scleroderma guani

Q CHEN, H LIANG, Q ZHANG - Chinese Journal of Biological Control, 2006 - zgswfz.com.cn
female wasps reared on 1-2 d old T. molitor pupae showed higher parasitism rate and
fecundity and produced more progeny wasps than those reared on 3-4 d and 5-6 d old pupae …

A study on the key technology of the online measurement device for joint internal thread

Q Zhou, ZQ Shuang - Applied Mechanics and Materials, 2015 - Trans Tech Publ
This paper describes the design and realization of an online measurement device used for
Joint Internal Thread. The online measurement device adopts the principle that the shaft …