[HTML][HTML] MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN
…, Y Xiao, W Guang-Xiu, J Zhi-Fan, P Pei-Yu, Z Qing-Yu… - BMC cancer, 2010 - Springer
Background MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor
genes via regulation of cell proliferation and/or apoptosis. MiR-221 and miR-222 were …
genes via regulation of cell proliferation and/or apoptosis. MiR-221 and miR-222 were …
Characterization of human small intestinal cytochromes P-450
QY Zhang, D Dunbar, A Ostrowska, S Zeisloft… - Drug Metabolism and …, 1999 - ASPET
Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P-450
(CYP)-catalyzed metabolism of orally ingested xenobiotics. The CYP composition of …
(CYP)-catalyzed metabolism of orally ingested xenobiotics. The CYP composition of …
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4 …
T Su, Z Bao, QY Zhang, TJ Smith, JY Hong, X Ding - Cancer research, 2000 - AACR
The human CYP2A subfamily comprises three genes, CYP2A6, CYP2A7, and CYP2A13.
CYP2A6 is active toward many carcinogens and is the major coumarin 7-hydroxylase and …
CYP2A6 is active toward many carcinogens and is the major coumarin 7-hydroxylase and …
Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats
Y Pan, XY Chen, QY Zhang, LD Kong - Brain, behavior, and immunity, 2014 - Elsevier
Depression is an inflammatory disorder. Pro-inflammatory cytokine interleukin-1 beta (IL-1β)
may play a pivotal role in the central nervous system (CNS) inflammation of depression. …
may play a pivotal role in the central nervous system (CNS) inflammation of depression. …
Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.
Human macrophages are believed to damage host tissues in chronic inflammatory disease
states, but these cells have been reported to express only modest degradative activity in vitro…
states, but these cells have been reported to express only modest degradative activity in vitro…
The small intestine as a xenobiotic-metabolizing organ
LS Kaminsky, QY Zhang - Drug metabolism and disposition, 2003 - ASPET
The mammalian small intestine serves principally as the site for absorption of nutrients, water,
and both beneficial and potentially harmful xenobiotics. However, it has become apparent …
and both beneficial and potentially harmful xenobiotics. However, it has become apparent …
[HTML][HTML] Natural product interventions for chemotherapy and radiotherapy-induced side effects
QY Zhang, FX Wang, KK Jia, LD Kong - Frontiers in pharmacology, 2018 - frontiersin.org
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy
are the common cancer treatments. However, the development of adverse effects resulting …
are the common cancer treatments. However, the development of adverse effects resulting …
Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation
X Zhang, JH Zhang, XY Chen, QH Hu… - Antioxidants & redox …, 2015 - liebertpub.com
Aims: Increased fructose consumption predisposes the liver to nonalcoholic fatty liver disease
(NAFLD), but the mechanisms are elusive. Thioredoxin-interacting protein (TXNIP) links …
(NAFLD), but the mechanisms are elusive. Thioredoxin-interacting protein (TXNIP) links …
[HTML][HTML] Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation
C Wang, Y Pan, QY Zhang, FM Wang, LD Kong - PloS one, 2012 - journals.plos.org
Hyperuricemia, hyperlipidemia and inflammation are associated with diabetic nephropathy.
The NLRP3 inflammasome-mediated inflammation is recently recognized in the …
The NLRP3 inflammasome-mediated inflammation is recently recognized in the …
[HTML][HTML] Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of …
A mouse model with liver-specific deletion of the NADPH-cytochrome P450 reductase (Cpr)
gene (designated Alb-Cre/Cpr lox mice) was generated and characterized in this study. …
gene (designated Alb-Cre/Cpr lox mice) was generated and characterized in this study. …