Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain
…, M Dokania, S Elavazhagan, P Vattikundala… - … of Pharmacology and …, 2016 - ASPET
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute
and persistent pain behavior assays. One of the lines from this screen, which contained a …
and persistent pain behavior assays. One of the lines from this screen, which contained a …
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable …
…, K Dandapani, M Dokania, P Vattikundala… - Journal of Medicinal …, 2022 - ACS Publications
Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as
a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have …
a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have …
Discovery and optimization of biaryl alkyl ethers as a novel class of highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) …
…, K Dandapani, M Dokania, P Vattikundala… - Journal of Medicinal …, 2022 - ACS Publications
Recent mouse knockout studies identified adapter protein-2-associated kinase 1 (AAK1) as
a viable target for treating neuropathic pain. BMS-986176/LX-9211 (4), as a highly selective, …
a viable target for treating neuropathic pain. BMS-986176/LX-9211 (4), as a highly selective, …
[PDF][PDF] Ameliorative effect of morin hydrate, a flavonoid against gentamicin induced oxidative stress and nephrotoxicity in sprague-dawley rats
…, S Pittala, M Lahkar, V Pradeep - International Journal of …, 2013 - researchgate.net
Objective: Morin Hydrate was recently shown to provide a protection of cultured rat glomerular
cells in vitro against oxyradical damage, and as a anticancer agent through inhibition of …
cells in vitro against oxyradical damage, and as a anticancer agent through inhibition of …
Genome-wide association studies of low back pain and lumbar spinal disorders using electronic health record data identify a locus associated with lumbar spinal …
Identifying genetic risk factors for lumbar spine disorders may lead to knowledge regarding
underlying mechanisms and the development of new treatments. We conducted a genome-…
underlying mechanisms and the development of new treatments. We conducted a genome-…
In Vitro antimalarial activity of chalcone and its derivatives
MI Sulistyowati, KA Nofianti… - International Journal of …, 2013 - repository.unair.ac.id
Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The
Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain…
Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain…