… Author links open overlay panel Paul Morgan 1 , Piet H. Van Der Graaf 1 2 , John Arrowsmith
3 , Doug E. Feltner 4 , Kira S. Drummond 5 , Craig D. … PH Van der Graaf, N. Benson …

Complex models of biochemical reaction systems have become increasingly common in the
systems biology literature. The complexity of such models can present a number of …

The combination of drugs is a common practice for enhancing the efficiency of drug treatment,
but selection of the optimal combination and the optimal doses remains a matter of trial …

Mechanistic PKPD models are now advocated not only by academic and industrial
researchers, but also by regulators. A recent development in this area is based on the growing …

Lack of predictability of clinical efficacy and safety is an important problem facing pharmaceutical
research today. Translational PK–PD has the ability to integrate data generated from …

It is generally accepted that, in conjunction with pharmacokinetics, the first-order rate constant
of target dissociation is a major determinant of the time course and duration of in vivo …

Novel developments in biomarkers discovery are essential in modern health care, notably
in treatment individualization and precision medicine. Clinical metabolomics, which aims to …

Personalized medicine, in modern drug therapy, aims at a tailored drug treatment accounting
for inter-individual variations in drug pharmacology to treat individuals effectively and safely…

Background Inhaled capsaicin elicits cough reproducibly in human subjects and is widely
used in the study of cough and antitussive therapies. However, the traditional end points C2 …

Collateral sensitivity (CS)-based antibiotic treatments, where increased resistance to one
antibiotic leads to increased sensitivity to a second antibiotic, may have the potential to limit the …