User profiles for Pierre Hardy

Pierre Hardy

university of montreal
Verified email at recherche-ste-justine.qc.ca
Cited by 5657

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

…, S Tremblay, M Leduc, L Rihakova, P Hardy… - Nature medicine, 2008 - nature.com
Vascularization is essential for tissue development and in restoration of tissue integrity after
an ischemic injury. In studies of vascularization, the focus has largely been placed on …

[HTML][HTML] Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid

…, WR Markesbery, AR Tapper, P Hardy… - Journal of Biological …, 1998 - ASBMB
F 2 -isoprostanes are prostaglandin F 2 -like compounds that are formed nonenzymatically
by free radical-induced oxidation of arachidonic acid. We explored whether oxidation of …

[HTML][HTML] Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life

…, F Sennlaub, P Hardy… - The Journal of …, 2010 - Am Soc Clin Investig
Retinopathy of prematurity (ROP) is a major complication of preterm birth. It encompasses a
spectrum of pathologies that affect vision, from mild disease that resolves spontaneously to …

Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy

P Hardy, I Dumont, M Bhattacharya, X Hou… - Cardiovascular …, 2000 - academic.oup.com
The choroid is the main source of oxygen to the retina. In contrast to the adult, the absence
of autoregulation of choroidal blood flow in the newborn leads to hyperoxygenation of the …

Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A

…, JC Honoré, C Quiniou, JS Joyal, P Hardy… - … , and vascular biology, 2013 - Am Heart Assoc
Objective— Proinflammatory cytokines contribute to the development of retinal vasculopathies.
However, the role of these factors and the mechanisms by which they elicit their effects in …

Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways

…, JC Lavoie, S Chemtob, P Hardy - American Journal …, 2008 - journals.physiology.org
Recent studies have demonstrated that lymphocyte-derived microparticles (LMPs) impair
endothelial cell function. However, no data currently exist regarding the contribution of LMPs in …

A novel mechanism for vasoconstrictor action of 8-isoprostaglandin F on retinal vessels

I Lahaie, P Hardy, X Hou… - American Journal …, 1998 - journals.physiology.org
Using a video-imaging technique, we characterized the effects of 8-isoprostaglandin F 2α (8-iso-PGF
2α ) on retinal vasculature from piglets. 8-Iso-PGF 2α potently contracted (EC 50 = …

[HTML][HTML] CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits

…, W Lubell, A Dorfman, J Racine, P Hardy… - Aging (Albany …, 2010 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) represents the major cause of vision loss in
industrialized nations. Laminar deposits in Bruch's membrane (BM) are among the first prominent …

The dual regulatory role of MiR-181a in breast cancer

C Yang, SN Tabatabaei, X Ruan, P Hardy - Cellular Physiology and …, 2017 - karger.com
MicroRNAs (miRNAs) are a family of highly conserved noncoding single˗stranded RNA
molecules of 21 to 25 nucleotides. miRNAs silence their cognate target genes at the post-…

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

…, R Ebady, H Zhou, T Odisho, PO Hardy… - Molecular …, 2012 - Wiley Online Library
Systemic dissemination of microbial pathogens permits microbes to spread from the initial
site of infection to secondary target tissues and is responsible for most mortality due to …