Requirement of bic/microRNA-155 for Normal Immune Function

A Rodriguez, E Vigorito, S Clare, MV Warren, P Couttet… - Science, 2007 - science.org
MicroRNAs are a class of small RNAs that are increasingly being recognized as important
regulators of gene expression. Although hundreds of microRNAs are present in the …

Discovery of roblitinib (FGF401) as a reversible-covalent inhibitor of the kinase activity of fibroblast growth factor receptor 4

…, F Adler, A Buhles, H Schadt, P Couttet… - Journal of medicinal …, 2020 - ACS Publications
FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key
driver of growth and survival in a subset of hepatocellular carcinomas, making selective …

Methodological considerations for measuring biofluid-based microRNA biomarkers

…, PST Yuen, RJ Church, P Couttet… - Critical reviews in …, 2021 - Taylor & Francis
MicroRNAs (miRNAs) are small non-coding RNA that regulate the expression of messenger
RNA and are implicated in almost all cellular processes. Importantly, miRNAs can be …

[HTML][HTML] Perturbation of microRNAs in rat heart during chronic doxorubicin treatment

…, F Staedtler, MP Vidgeon-Hart, O Grenet, P Couttet - 2012 - journals.plos.org
Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors)
is limited by adverse effects of these compounds on the cardiovascular system, ultimately …

FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of FGF19-driven hepatocellular cancer

…, J Kinyamu-Akunda, HS Schadt, P Couttet… - Molecular Cancer …, 2019 - AACR
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it
is the third leading cause of cancer-related deaths worldwide. Recently, aberrant signaling …

[HTML][HTML] Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions

…, R Stull, D Theil, JG Moggs, E Marrer, P Couttet - PloS one, 2013 - journals.plos.org
MicroRNAs are short non-coding RNAs that regulate gene expression at the post-transcriptional
level and play key roles in heart development and cardiovascular diseases. Here, we …

[HTML][HTML] Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice

…, N Zamurovic, A Vicart, E Funhoff, P Couttet… - PloS one, 2011 - journals.plos.org
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated
with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. …

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

…, H Hara, F Picard, D Theil, P Couttet… - Toxicological …, 2014 - academic.oup.com
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely
related nuclear receptors involved in drug metabolism and play important roles in the …

Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion

H Lempiäinen, P Couttet, F Bolognani… - Toxicological …, 2013 - academic.oup.com
The molecular events during nongenotoxic carcinogenesis and their temporal order are
poorly understood but thought to include long-lasting perturbations of gene expression. Here, …

Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies

A Wolf, P Couttet, M Dong, O Grenet, M Heron… - Leukemia research, 2010 - Elsevier
Cytotoxic concentrations of imatinib mesylate (10–50μM) were required to trigger markers of
apoptosis and endoplasmic reticulum stress response in neonatal rat ventricular myocytes …