Acetaminophen-induced hepatotoxicity

LP James, PR Mayeux, JA Hinson - Drug metabolism and disposition, 2003 - ASPET
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when
taken in overdose. The initial phases of toxicity were described in Dr. Gillette's laboratory in …

The endothelium in sepsis

C Ince, PR Mayeux, T Nguyen, H Gomez, JA Kellum… - Shock, 2016 - journals.lww.com
Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the
key factor in the progression from sepsis to organ failure. Endothelial functions affected by …

Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species

SL Michael, NR Pumford, PR Mayeux… - …, 1999 - Wiley Online Library
Hepatotoxic doses of acetaminophen to mice produce not only acetaminophen‐protein
adducts in the centrilobular cells of the liver, but nitrotyrosine‐protein adducts in the same cells, …

Nitrotyrosine− protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice

…, SL Pike, NR Pumford, PR Mayeux - Chemical research in …, 1998 - ACS Publications
Treatment of mice with a toxic dose of acetaminophen (300 mg/kg, ip) significantly increased
hepatotoxicity at 4 h, as evidenced by histological necrosis in the centrilobular areas of the …

Pathobiology of lipopolysaccharide

PR Mayeux - Journal of toxicology and environmental health, 1997 - Taylor & Francis
Lipopolysaccharide is a component of the gram-negative bacterial cell wall that is
responsible for 25,000-50,000 deaths in the United States each year. The sequelae of gram-negative …

Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance …

…, HP Hendrickson, JA Hinson, PR Mayeux - Drug metabolism and …, 2002 - ASPET
Acetaminophen-induced hepatotoxicity has been attributed to covalent binding of the
reactive metaboliteN-acetyl-p-benzoquinone imine to cysteine groups on proteins as an …

[HTML][HTML] Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury

…, Z Wang, KA Seely, N Gokden, PR Mayeux - Kidney international, 2012 - Elsevier
The mortality rate of patients who develop acute kidney injury during sepsis nearly doubles.
The effectiveness of therapy is hampered because it is usually initiated only after the onset …

[HTML][HTML] Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury

…, HJ Spencer III, N Gokden, PR Mayeux - The American journal of …, 2012 - Elsevier
Acute kidney injury is a frequent and serious complication of sepsis. To better understand
the development of sepsis-induced acute kidney injury, we performed the first time-dependent …

Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury

…, LA MacMillan-Crow, PR Mayeux - American Journal of …, 2014 - journals.physiology.org
Acute kidney injury (AKI) is a complication of sepsis and leads to a high mortality rate. Human
and animal studies suggest that mitochondrial dysfunction plays an important role in sepsis…

Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury

L Wu, N Gokden, PR Mayeux - Journal of the American Society of …, 2007 - journals.lww.com
Acute kidney injury (AKI) remains a frequent and serious complication of human sepsis that
contributes significantly to mortality. For better understanding of the development of AKI …