Mechanisms of arsenic-induced prolongation of cardiac repolarization

…, AT Dennis, C Obejero-Paz, L Wang, P Hawryluk… - Molecular …, 2004 - ASPET
Arsenic trioxide (As 2 O 3 ) produces dramatic remissions in patients with relapsed or refractory
acute promyelocytic leukemia. Its clinical use is burdened by QT prolongation, torsade …

Pentamidine-induced long QT syndrome and block of hERG trafficking

YA Kuryshev, E Ficker, L Wang, P Hawryluk… - … of Pharmacology and …, 2005 - ASPET
The diamidine pentamidine is used to treat leishmaniasis, trypanosomiasis, and Pneumocystis
carinii pneumonia. Treatment may be accompanied by prolongation of the QT interval of …

HERG-LiteŽ: A novel comprehensive high-throughput screen for drug-induced hERG risk

BA Wible, P Hawryluk, E Ficker, YA Kuryshev… - … of pharmacological and …, 2005 - Elsevier
INTRODUCTION: Direct block of I Kr by non-antiarrhythmic drugs (NARDs) is a major cause
of QT prolongation and torsades de pointes (TdP), and has made the hERG potassium …

[HTML][HTML] Quantitative profiling of the effects of vanoxerine on human cardiac ion channels and its application to cardiac risk

…, A Bruening-Wright, J Kramer, P Hawryluk… - Scientific reports, 2015 - nature.com
Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but
lacked efficacy. Although a potent blocker of hERG, it produced no serious adverse events. …

Characterization of a novel RNA polymerase II arrest site which lacks a weak 3′ RNA–DNA hybrid

PJ Hawryluk, A Újvári, DS Luse - Nucleic acids research, 2004 - academic.oup.com
Transcript elongation by RNA polymerase II is blocked at DNA sequences called arrest sites.
An exceptionally weak RNA–DNA hybrid is often thought to be necessary at the point of …

[PDF][PDF] Comparison of in-cell immunoassay and automated electrophysiology for assessment of hERG trafficking liability for new drugs

Y Kuryshev, P Hawryluk, C Wu, A Sewell, J Kramer… - Pharmacol …, 2005 - criver.com
… Yuri Kuryshev, Peter Hawryluk, Caiyun Wu, Abby Sewell, James Kramer, Carlos Obejero-Paz,
Luke Armstrong, Arthur M. Brown Charles River, Cleveland, Ohio, USA … hERG-LiteŽ …

[CITATION][C] How Bush Manages Foreign Policy: An Early Assessment

PK Hawryluk - 1990 - dataspace.princeton.edu
DataSpace: How Bush Manages Foreign Policy: An Early Assessment Skip navigation
DataSpace About Contact Help Search Explore All Communities & Collections …

Selected Muslim historic monuments and sites in Bulgaria

SD Gruber - 2010 - surface.syr.edu
2010 report from the United States Commission for the Preservation of America's Heritage
Abroad on historic Muslim monuments and sites in Bulgaria. Includes information on the …

Jewish Heritage Sites and Monuments in Moldova

SD Gruber - 2010 - surface.syr.edu
2010 report from the United States Commission for the Preservation of America's Heritage
Abroad on historic Jewish sites in Romania. Includes information on the history and current …

[CITATION][C] Characterization of an unusual RNA polymerase II arrest site

PJ Hawryluk - 2002 - Case Western Reserve University