[PDF][PDF] Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver
…, J Bonnardel, N Vandamme, A Kremer, P Borghgraef… - Immunity, 2020 - cell.com
Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, …
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, …
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
…, E Rosen, P Borghgraef… - Proceedings of the …, 2006 - National Acad Sciences
Epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs)
decrease the risk for Alzheimer's disease (AD). Certain NSAIDs can activate the peroxisome …
decrease the risk for Alzheimer's disease (AD). Certain NSAIDs can activate the peroxisome …
[PDF][PDF] Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche
…, A Kremer, E Van Hamme, P Borghgraef… - Immunity, 2019 - cell.com
Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the
cell-cell interactions that imprint the tissue-specific identities of macrophages in their …
cell-cell interactions that imprint the tissue-specific identities of macrophages in their …
Amyloid activates GSK-3β to aggravate neuronal tauopathy in bigenic mice
…, D Muyllaert, I Dewachter, P Borghgraef… - The American journal of …, 2008 - Elsevier
The hypothesis that amyloid pathology precedes and induces the tau pathology of Alzheimer's
disease is experimentally supported here through the identification of GSK-3 isozymes as …
disease is experimentally supported here through the identification of GSK-3 isozymes as …
[HTML][HTML] Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice
…, C Van Haesendonck, P Borghgraef… - Journal of Biological …, 2005 - ASBMB
Protein tau-3R/4R isoform ratio and phosphorylation regulates binding to microtubules and,
when disturbed by aging or mutations, results in diverse tauopathies and in …
when disturbed by aging or mutations, results in diverse tauopathies and in …
[HTML][HTML] Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau. P301L mice that model tauopathy
…, O Adolfsson, N Chuard, DM Ndao, P Borghgraef… - PloS one, 2013 - journals.plos.org
Progressive aggregation of protein Tau into oligomers and fibrils correlates with cognitive
decline and synaptic dysfunction, leading to neurodegeneration in vulnerable brain regions in …
decline and synaptic dysfunction, leading to neurodegeneration in vulnerable brain regions in …
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
…, D Terwel, B Biemans, P Borghgraef… - Journal of …, 2006 - Soc Neuroscience
The microtubule binding protein tau is implicated in neurodegenerative tauopathies, including
frontotemporal dementia (FTD) with Parkinsonism caused by diverse mutations in the tau …
frontotemporal dementia (FTD) with Parkinsonism caused by diverse mutations in the tau …
[HTML][HTML] Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration
…, D Demedts, L Gielis, H Devijver, P Borghgraef… - The American journal of …, 2011 - Elsevier
Adeno-associated virus (AAV)–mediated expression of wild-type or mutant P301L protein tau
produces massive degeneration of pyramidal neurons without protein tau aggregation. We …
produces massive degeneration of pyramidal neurons without protein tau aggregation. We …
Mice lacking phosphatase PP2A subunit PR61/B'δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β
JV Louis, E Martens, P Borghgraef… - Proceedings of the …, 2011 - National Acad Sciences
Functional diversity of protein phosphatase 2A (PP2A) enzymes mainly results from their
association with distinct regulatory subunits. To analyze the functions of one such holoenzyme …
association with distinct regulatory subunits. To analyze the functions of one such holoenzyme …
Deregulation of NMDA-receptor function and down-stream signaling in APP [V717I] transgenic mice
…, D Terwel, M Gysemans, H Devijver, P Borghgraef… - Neurobiology of …, 2009 - Elsevier
Evidence is accumulating for a role for amyloid peptides in impaired synaptic plasticity and
cognition, while the underlying mechanisms remain unclear. We here analyzed the effects of …
cognition, while the underlying mechanisms remain unclear. We here analyzed the effects of …