Postreplicative mismatch repair plays a major role in mediating the cytotoxicity of agents
generatingO 6 -methylguanine in DNA. We previously showed that a methylating antitumor …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Poly(ADP-ribose) polymerase (PARP)-1 has recently been shown to promote tumour
progression. Since angiogenesis is an essential requirement for tumour growth, we examined …

… Author links open overlay panel Pedro Miguel Lacal a , Grazia Graziani b … In contrast,
M2 TAMs are originated in the presence of growth factors such as M-CSF and of CD4+T cell-…

The immune checkpoint cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is an inhibitory
regulator of T-cell mediated responses that has been investigated as target of monoclonal …

Reduced microcirculation and diminished expression of growth factors contribute to wound
healing impairment in diabetes. Placenta growth factor (PlGF), an angiogenic mediator …

Melanoma is the most aggressive form of skin cancer and, if spread outside the epidermis,
has a dismal prognosis. Before the approval of the anti-cytotoxic T lymphocyte-associated …

Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor for
several growth factors of the VEGF family. Endothelial cells express a membrane-spanning …

Ellagic acid (EA) is a naturally occurring polyphenolic compound endowed with strong
antioxidant and anticancer properties that is present in high quantity in a variety of berries, …

Simple Summary Stimulation of the host immune responses, through the use of biotech
drugs that remove a brake on the immune system (immune checkpoint inhibitors), is a current …