Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as
migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the …

The cross-talk between receptor tyrosine kinases and integrin receptors are known to be
crucial for a number of cellular functions. On endothelial cells, an interaction between integrin α …

The idea of antiangiogenic therapy was the brainchild of D r. J udah F olkman in the early
1970s. He proposed that by cutting off the blood supply, cancer cells would be deprived of …

Loss of the blood-retinal barrier (BRB) integrity and subsequent damage to the neurovascular
unit in the retina are the underlying reasons for diabetic retinopathy (DR). Damage to BRB …

Prostate cancer is the second-leading cause of cancer-associated death among men in the
United States. There has been renewed interest in the potential therapeutic benefits of …

The Src-family kinases (SFKs), an intracellularly located group of non-receptor tyrosine
kinases are involved in oncogenesis. The importance of SFKs has been implicated in the …

A sequence of events in vascular and stromal cells maintained in a highly coordinated
manner regulates angiogenesis and tissue remodeling. These processes are mediated by the …

Importance of the field: P21-activated kinases (PAKs) are involved in multiple signal
transduction pathways in mammalian cells. PAKs, and PAK1 in particular, play a role in such …

Epithelial and endothelial cell-cell contacts are established and maintained by several
intercellular junctional complexes. These structurally and biochemically differentiated regions on …