IGF-1 is downregulated in experimental cancer cachexia
…, M Bossola, F Penna, P Reffo… - American Journal …, 2006 - journals.physiology.org
Cancer cachexia is characterized by skeletal muscle wasting that is mainly supported by
hypercatabolism. Muscle atrophy has been suggested to depend on impaired IGF-1 signal …
hypercatabolism. Muscle atrophy has been suggested to depend on impaired IGF-1 signal …
Ca2+-dependent proteolysis in muscle wasting
P Costelli, P Reffo, F Penna, R Autelli, G Bonelli… - The international journal …, 2005 - Elsevier
Skeletal muscle wasting is a prominent feature of cachexia, a complex systemic syndrome
that frequently complicates chronic diseases such as inflammatory and autoimmune disorders…
that frequently complicates chronic diseases such as inflammatory and autoimmune disorders…
Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress
R Mastrocola, P Reffo, F Penna, CE Tomasinelli… - Free Radical Biology …, 2008 - Elsevier
Cachexia is a debilitating syndrome characterized by body weight loss, muscle wasting,
and anemia. Muscle wasting results from an altered balance between protein synthesis and …
and anemia. Muscle wasting results from an altered balance between protein synthesis and …
4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line
…, P Bardini, S Pizzimenti, C Toaldo, P Reffo… - Free Radical Biology …, 2005 - Elsevier
4-Hydroxynonenal (HNE), a product of lipid peroxidation, inhibits proliferation of several
tumor cells. The p53 tumor suppressor protein plays a critical role in cell cycle control, by …
tumor cells. The p53 tumor suppressor protein plays a critical role in cell cycle control, by …
Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by tumor necrosis factor-α
A Bonetto, F Penna, VG Minero, P Reffo… - Amino acids, 2011 - Springer
Depletion of skeletal muscle protein mainly results from enhanced protein breakdown,
caused by activation of proteolytic systems such as the Ca2+-dependent and the ATP-ubiquitin-…
caused by activation of proteolytic systems such as the Ca2+-dependent and the ATP-ubiquitin-…
[HTML][HTML] Mice lacking TNFα receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody
P Costelli, P Aoki, B Zingaro, N Carbo, P Reffo… - Cell Death & …, 2003 - nature.com
The liver is particularly susceptible to Fas-mediated cytotoxicity. Mice given an adequate
parenteral dose of agonistic anti-Fas antibody (aFas) or of FasL are known to develop a …
parenteral dose of agonistic anti-Fas antibody (aFas) or of FasL are known to develop a …
Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells
…, F Briatore, A Fraioli, M Maggio, P Reffo… - … of Pharmacology and …, 2003 - ASPET
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors.
Three subtypes of PPARs (α, β, and γ) have been identified in different tissues. PPARα and …
Three subtypes of PPARs (α, β, and γ) have been identified in different tissues. PPARα and …
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells
DD Stefanis, P Reffo, G Bonelli, FM Baccino, G Sala… - 2002 - degruyter.com
Ceramide has been suggested as an important mediator of apoptosis. In HT-29 colorectal
cancer cells increased ceramide levels, induced by exogenous Nacetylsphingosine (NAS, …
cancer cells increased ceramide levels, induced by exogenous Nacetylsphingosine (NAS, …
Mechanisms involved in growth inhibition induced by clofibrate in hepatoma cells
…, M Maggiora, A Trombetta, G Martinasso, P Reffo… - Toxicology, 2003 - Elsevier
Low concentrations of some peroxisome proliferators have been found to decrease apoptosis
in rat liver cells, whereas higher but pharmacological concentrations have been found to …
in rat liver cells, whereas higher but pharmacological concentrations have been found to …
Modulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy
P Costelli, V Almendro, MT Figueras, P Reffo… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Calcineurin has been proposed to regulate skeletal muscle hypertrophy, while its relevance
to the pathogenesis of muscle atrophy is unknown. The present study was aimed to …
to the pathogenesis of muscle atrophy is unknown. The present study was aimed to …