In recent years the etiopathology of a number of debilitating diseases such as type 2 diabetes,
arthritis, atherosclerosis, psoriasis, asthma, cystic fibrosis, sepsis, and ulcerative colitis …

Agonists of nicotinic acetylcholine receptors (nAChRs) produce long-lasting cognitive
efyfects in animal models and humans. The duration of these cognitive effects can outlast the …

Type 2 diabetes has become a pervasive public health problem. The etiology of the disease
has not been fully defined but appears to involve abnormalities in peripheral and central …

Both clinical and preclinical data support a potential therapeutic benefit of modulating the
activity of CNS neuronal nicotinic receptors (NNRs) to treat depression and anxiety disorders. …

Smokers are reported to have a higher density of central nicotinic acetylcholine receptors (nAChRs)
that non-smokers at autopsy. Whether this increased receptor density is a response …

There is a consensus that high-affinity [3H]-L-nicotine binding sites in the mammalian brain,
which are thought to represent a predominant form of central nervous system nicotinic …

Inflammatory disorders are characterized by the influx of immune cells into the vascular wall
of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. …

The binding of optically pure L-[3H]nicotine to rat brain membrane preparations was studied
using a rapid filtration method. The binding properties observed depended on the method …

The properties of high affinity nicotine-binding sites in rat brain were studied by monitoring
the kinetics of L-[3H]nicotine binding to whole brain membrane preparations, including both …

The long prevailing hypothesis of schizophrenia pathogenesis implicates dopaminergic
systems in the mesolimbic pathways as responsible for the positive symptoms of schizophrenia (…