Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

Essential to the construction, maintenance and repair of tissues is the ability to induce suicide
of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study …

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types
of human cancer and are associated with chemoresistance, disease progression and poor …

A better understanding of the mechanisms through which anticancer drugs exert their effects
is essential to improve combination therapies. While studying how genotoxic stress kills …

DURING closure of the neural tube in the mouse, transcription factor AP-2 (refs 1–4) is
expressed in ectoderm and in neural-crest cells migrating from the cranial neural folds 5 . Cranial …

Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For
patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in …

Background— The prognostic relevance of the collateral circulation is still controversial. The
goal of this study was to assess the impact on survival of quantitatively obtained, recruitable …

Aims The coronary collateral circulation as an alternative source of blood supply has shown
benefits regarding several clinical endpoints in patients with myocardial infarction (MI) such …

We have isolated the recently identified Drosophila caspase DRONC through its interaction
with the effector caspase drICE. Ectopic expression of DRONC induces cell death in …