Ingestion of toxin, traumatic events, adverse drug reactions, and motion can all result in
nausea and emesis. In addition, cyclic vomiting syndrome is quite prevalent in the pediatric …

Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the
market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 …

Oil of mustard (OM) is a potent neuronal activator that is known to elicit visceral hyperalgesia
when given intracolonically, but the full extent to which OM is also proinflammatory in the …

Monoclonal antibody (mAb) engineering that optimizes binding to receptors present on
brain vascular endothelial cells has enabled them to cross through the blood–brain barrier (BBB) …

Physiologically relevant sources of absorptive intestinal epithelial cells are crucial for human
drug transport studies. Human adenocarcinoma-derived intestinal cell lines, such as Caco-2…

The lower esophageal sphincter is innervated by both parasympathetic (vagus) and
sympathetic (primarily splanchnic) nerves; however, the vagal pathways are the ones that are …

From a historical perspective to the present day, all the evidence suggests that activation of
cannabinoid receptors (CBRs) is beneficial for gut discomfort and pain, which are symptoms …

The Na + -glucose cotransporter 1 (SGLT1/SLC5A1) is predominantly expressed in the
small intestine. It transports glucose and galactose across the apical membrane in a process …

Purpose To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn)
in adult primate intestine to determine whether this is a means for oral delivery of …

Our purpose was to determine the central vagal sites for regulating changes in lower
esophageal sphincter (LES) pressure in the cat. Injection of the retrograde tracer, horseradish …