Antibiotic treatments have been used to modulate intestinal bacteria and investigate the role
of intestinal bacteria on bile acid (BA) homeostasis. However, knowledge on which …

Previous studies from our laboratory have demonstrated that hepatocytes can transdifferentiate
into biliary epithelium (BE) both in vivo and in vitro; however, the mechanisms are unclear…

Transcription factors are major determinants of cell-specific gene expression in all cell types.
Studies in rodent liver have shown that alterations in transcription factor expression …

Liver injury is known to progress even after the hepatotoxicant is long gone and the
mechanisms of progressive injury are not understood. We tested the hypothesis that hydrolytic …

Calpain is a Ca 2+ -regulated cytosolic cysteine protease that exists mainly in two isoforms
and mediates crucial cellular functions, including rearrangement of cytoskeletal proteins, …

Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood‐onset
developmental and epileptic encephalopathies (eg, Dravet syndrome). To assess risk …

Moderate dietary or caloric restriction (DR) modulates animal physiology in a beneficial
fashion. Previously, we have reported an equitoxic dose experiment where liver injury in DR …

There is a need for well characterized and economical type 2 diabetic model that mimics the
human disease. We have developed a type 2 diabetes rat model that closely resembles the …

Previously we reported that moderate calorie restriction or diet restriction (DR, calories
reduced by 35% for 21 days) in male Sprague-Dawley rats protects from a lethal dose of …

Organic anion transporting polypeptide 1a1 (Oatp1a1) is predominantly expressed in liver
and is able to transport bile acids (BAs) in vitro. Male Oatp1a1-null mice have increased …