Nonsteroidal anti-inflammatory drugs and sulfinpyrazone compete dose-dependently with
arachidonate for binding to platelet cyclooxygenase. Such a process closely follows systemic …

… Citation19,Citation27,Citation42,Citation47 – Citation52 Figures 2B and 2C reprinted from
García Rodríguez LA, Tacconelli S, Patrignani P. Role of dose potency in the prediction of risk …

… The human whole blood in vitro assay developed by Paola Patrignani and colleagues [52]
has been used to measure the degree of selectivity of NSAIDs toward COX-2 or COX-1 by …

Acetylation of platelet cyclooxygenase by oral aspirin is dose dependent and cumulative
with repeated administration. However, no single dose of aspirin has been found to be …

The aim of our study was to characterize a model of human prostaglandin endoperoxide
synthase-2(PGHS-2) expression allowing the assessment of pharmacological inhibition in vitro …

… A probability value of p < 0.05 was considered to be statistically significant. The primary
hypothesis was that naproxen (500 mg, BID), administered 2 h before aspirin, would interfere …

Objectives : We studied the association between the frequency, dose, and duration of different
nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of myocardial infarction (MI) in …

… P values are for the heterogeneity test results; n values are the number of studies. ∗︁ = … A
statistically significant correlation (r 2 = 0.98, P < 0.0001) between the 2 sets of estimates of RR …

Colorectal cancer 0.4–0.7 Acute renal failure 0.02–0.08 separate the participation of COX-1
in physiological processes and COX-2 in pathological processes (4), it is not yet clear how …

… In RVD patients, urinary 8-iso-PGF 2α correlated with 11-dehydro-TXB 2 (r s =0.48; P<0.05)
and renal vein renin (r s =0.67; P<0.005) and angiotensin II (r s =0.65; P=0.005) ratios. A …