… compounds were first identified from rat stomach (32), and PGI2 was subsequently shown
to be responsible for arachi donate-induced coronary vasodilation observed by Needleman …

This review focuses on the recent discovery of atriopeptin, a peptide hormone that is intimately
involved in the regulation of renal and cardiovascular homeostasis. This peptide, which is …

We have evaluated the role of nitric oxide (NO) on the activity of the constitutive and induced
forms of cyclooxygenase (COX; COX-1 and COX-2, respectively). Induction of NO synthase (…

Platelets enzymatically convert prostaglandin H 3 (PGH 3 ) into thromboxane A 3 . Both
PGH 2 and thromboxane A 2 aggregate human platelet-rich plasma. In contrast, PGH 3 and …

We report here that the bacterial lipopolysaccharide endotoxin induces human blood
monocytes in a time- and dose-dependent manner to release prodigious amounts of …

The microsomal fraction of horse and human platelets contains an enzyme which converts
prostaglandin cyclic endoperoxides (PGG 2 or PGH 2 ) to a substance which is much more …

… Raz, and P. Needleman. 1990. The induction and suppression of prostaglandin H2 synthase
(… Needleman. 1981. Differential biosynthesis of prostaglandins by hydronephrotic rabbit and …

The effect of endogenous glucocorticoids on the expression of the cyclooxygenase enzyme
was studied by contrasting cyclooxygenase expression and prostanoid synthesis in …

NUMEROUS observations have implicated hu-moral factors in the homeostatic regulation of
fluid and electrolyte balance. This review will focus on a recently discovered peptide that is …

An oligonucleotide probe was used to isolate a clone encoding prostaglandin endoperoxide
synthetase (cyclooxygenase, EC 1.14.99.1) from a sheep seminal vesicle cDNA library. The …