User profiles for P. M. O’Neill
Paul M. O'NeillDepartment of Chemistry Verified email at liv.ac.uk Cited by 17354 |
Artemisinins target the SERCA of Plasmodium falciparum
…, JM East, AG Lee, M Kimura, PM O'neill… - Nature, 2003 - nature.com
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent
antimalarials available 1 , rapidly killing all asexual stages of Plasmodium falciparum 2 . …
antimalarials available 1 , rapidly killing all asexual stages of Plasmodium falciparum 2 . …
Metabolism of fluorine-containing drugs
…, NR Kitteringham, PM O'Neill - Annual review of …, 2001 - annualreviews.org
… B Kevin Park, Neil R Kitteringham, and Paul M O'Neill … Therefore, the F…H bond is clearly
much weaker than the corresponding O…H (conservatively estimated to be ca 5 kcal mol −1 …
much weaker than the corresponding O…H (conservatively estimated to be ca 5 kcal mol −1 …
[HTML][HTML] The molecular mechanism of action of artemisinin—the debate continues
PM O'Neill, VE Barton, SA Ward - Molecules, 2010 - mdpi.com
Despite international efforts to ‘roll back malaria’ the 2008 World Malaria Report revealed
the disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …
the disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …
An XMM–Newton survey of broad iron lines in Seyfert galaxies
K Nandra, PM O'Neill, IM George… - Monthly Notices of the …, 2007 - academic.oup.com
We present an analysis of the X-ray spectra of a sample of 37 observations of 26 Seyfert
galaxies observed by XMM–Newton in order to characterize their iron Kα emission. All objects …
galaxies observed by XMM–Newton in order to characterize their iron Kα emission. All objects …
A medicinal chemistry perspective on artemisinin and related endoperoxides
PM O'Neill, GH Posner - Journal of medicinal chemistry, 2004 - ACS Publications
… Currently, O'Neill and Bachi groups are synthesising new versions of endoperoxide−chalcone
prodrugs incorporating chalcone units that have already been shown to display potent …
prodrugs incorporating chalcone units that have already been shown to display potent …
Transition of care for adolescents from paediatric services to adult health services
…, K Biggs, SK Aldiss, PM O'Neill… - … database of …, 2016 - cochranelibrary.com
Background There is evidence that the process of transition from paediatric (child) to adult
health services is often associated with deterioration in the health of adolescents with chronic …
health services is often associated with deterioration in the health of adolescents with chronic …
[HTML][HTML] Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
…, Z Rao, ZJ Liu, H Yang, L Zhang, PM O'Neill… - Nature …, 2021 - nature.com
… Electron density (2F o –F c ) map is shown as grey mesh at 1σ. Anomalous signal of selenium
is … SSH and PMO conceived the work. KA purified protein and performed crystallographic …
is … SSH and PMO conceived the work. KA purified protein and performed crystallographic …
4-Aminoquinolines—Past, present, and future; A chemical perspective
PM O'Neill, PG Bray, SR Hawley, SA Ward… - Pharmacology & …, 1998 - Elsevier
The 4-aminoquinoline chloroquine (1) can be considered to be one of the most important
synthetic chemotherapeutic agents in history. Since its discovery, chloroquine has proved to be …
synthetic chemotherapeutic agents in history. Since its discovery, chloroquine has proved to be …
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
…, J Hemingway, GA Biagini, PM O'Neill… - Proceedings of the …, 2016 - National Acad Sciences
The artemisinin (ART)-based antimalarials have contributed significantly to reducing global
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …
Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new …
GH Posner, PM O'Neill - Accounts of chemical research, 2004 - ACS Publications
… , eg, 2a and 2b, in order to avoid the presence of any oxidizable O-alkyl groups as in
artemether. O'Neill recently prepared in one step from DHA several C-10 phenoxy analogues 25a−f…
artemether. O'Neill recently prepared in one step from DHA several C-10 phenoxy analogues 25a−f…