Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in
many diverse cell types. It plays a major role in the development of inflammatory and …

Toll-like receptor 2 (TLR2) agonists induce a subset of TLR4-inducible proinflammatory
genes, which suggests the use of differential signaling pathways. Murine macrophages …

Overproduction of inflammatory mediators by macrophages in response to Gram-negative
LPS has been implicated in septic shock. Recent reports indicate that three membrane-…

The antitumor agent, Taxol, shares with bacterial LPS the ability to activate murine macrophages,
and its LPS-mimetic effects are blocked by LPS analogue antagonists. Since CD14 is …

Celiac disease (CD) is an autoimmune inflammatory disease with a relatively high prevalence
especially in the western hemisphere. A strong genetic component is involved in the …

Vascular disrupting agents (VDAs) represent a novel approach to the treatment of cancer,
resulting in the collapse of tumor vasculature and tumor death. 5,6-dimethylxanthenone-4-…

With the emerging success of treating CD19 expressing B cell malignancies with ex vivo
modified, autologous T cells that express CD19‐directed chimeric antigen receptors (CAR), …

Taxol, a microtubule stabilizing agent, exhibits promise in the treatment of breast and ovarian
tumors. Recently, this novel drug has been shown to activate murine macrophages to …

… LP Perera gratefully acknowledges the receipt of an invitational fellowship from the
Japan Society for the Promotion of Science. … Pin-Yu Perera … Pin-Yu Perera …

A point mutation in the Tlr4 gene, which encodes Toll-like receptor 4, has recently been
proposed to underlie LPS hyporesponsiveness in C3H/HeJ mice (Lps d). The data presented …