[HTML][HTML] Mitochondrial dynamics regulates migration and invasion of breast cancer cells
Mitochondria are highly dynamic and undergo constant fusion and fission that are essential
for maintaining physiological functions of cells. Although dysfunction of mitochondria has …
for maintaining physiological functions of cells. Although dysfunction of mitochondria has …
α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle
C Han, PW Abel, KP Minneman - Nature, 1987 - nature.com
Receptor-mediated increases in intracellular Ca 2+ levels can be caused by release from
intracellular organelles and/or influx from the extracellular fluid. Noradrenaline (NA) released …
intracellular organelles and/or influx from the extracellular fluid. Noradrenaline (NA) released …
Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4
…, B Wang, C Deng, JK Kirui, H Jiang, J Qin, PW Abel… - Cancer research, 2009 - AACR
Aberrant signaling through G-protein coupled receptors promotes metastasis, the major cause
of breast cancer death. We identified regulator of G-protein signaling 4 (RGS4) as a novel …
of breast cancer death. We identified regulator of G-protein signaling 4 (RGS4) as a novel …
[HTML][HTML] Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis
P Wei, Y Xie, PW Abel, Y Huang, Q Ma, L Li, J Hao… - Cell death & …, 2019 - nature.com
Transforming growth factor (TGF)-β1, a main profibrogenic cytokine in the progression of
idiopathic pulmonary fibrosis (IPF), induces differentiation of pulmonary fibroblasts to …
idiopathic pulmonary fibrosis (IPF), induces differentiation of pulmonary fibroblasts to …
TH17 cells and corticosteroid insensitivity in severe asthma
Y Xie, PW Abel, TB Casale, Y Tu - Journal of Allergy and Clinical …, 2022 - Elsevier
Asthma is classically described as having either a type 2 (T2) eosinophilic phenotype or a
non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation …
non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation …
[PDF][PDF] Comparison of alpha 1-adrenergic receptor subtypes distinguished by chlorethylclonidine and WB 4101.
KP Minneman, C Han, PW Abel - Molecular pharmacology, 1988 - Citeseer
We showed previously that subtypes of a1-adrenergic receptors can be differentiated by
selective inactivation with chlorethylclonidine (CEC)[Mo!. Pharmaco!. 32: 505-51 0 (1 987)] or by …
selective inactivation with chlorethylclonidine (CEC)[Mo!. Pharmaco!. 32: 505-51 0 (1 987)] or by …
Quantification of steady state expression of mRNA for alpha-1 adrenergic receptor subtypes using reverse transcription and a competitive polymerase chain reaction.
MA Scofield, F Liu, PW Abel, WB Jeffries - Journal of Pharmacology and …, 1995 - ASPET
Three distinct alpha-1 adrenergic receptor subtypes (alpha-1a, alpha-1b and alpha-1d)
have been identified through molecular cloning. Expression of alpha-1 adrenergic receptor …
have been identified through molecular cloning. Expression of alpha-1 adrenergic receptor …
Heterogeneity of alpha 1-adrenergic receptors revealed by chlorethylclonidine.
C Han, PW Abel, KP Minneman - Molecular pharmacology, 1987 - ASPET
Chlorethylclonidine (CEC) has previously been shown to inactivate only a subpopulation of
the alpha 1-adrenergic receptor binding sites in rat brain. We compared alpha 1-adrenergic …
the alpha 1-adrenergic receptor binding sites in rat brain. We compared alpha 1-adrenergic …
Respiratory dysfunction progresses with age in Kcna1‐null mice, a model of sudden unexpected death in epilepsy
…, SA Matthews, M Deodhar, PJ Oldenburg, PW Abel… - …, 2018 - Wiley Online Library
Objective Increased breathing rate, apnea, and respiratory failure are associated with
sudden unexpected death in epilepsy ( SUDEP ). We recently demonstrated the progressive …
sudden unexpected death in epilepsy ( SUDEP ). We recently demonstrated the progressive …
Gβγ signaling promotes breast cancer cell migration and invasion
JK Kirui, Y Xie, DW Wolff, H Jiang, PW Abel… - Journal of Pharmacology …, 2010 - ASPET
Signaling through G protein-coupled receptors (GPCRs) promotes breast cancer metastasis.
G proteins convey GPCR signals by dissociating into Gα and Gβγ subunits. The aim of the …
G proteins convey GPCR signals by dissociating into Gα and Gβγ subunits. The aim of the …