[HTML][HTML] Mitochondrial dynamics regulates migration and invasion of breast cancer cells

…, J Zhang, M Yu, Y Xie, Y Huang, DW Wolff, PW Abel… - Oncogene, 2013 - nature.com
Mitochondria are highly dynamic and undergo constant fusion and fission that are essential
for maintaining physiological functions of cells. Although dysfunction of mitochondria has …

α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle

C Han, PW Abel, KP Minneman - Nature, 1987 - nature.com
Receptor-mediated increases in intracellular Ca 2+ levels can be caused by release from
intracellular organelles and/or influx from the extracellular fluid. Noradrenaline (NA) released …

Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4

…, B Wang, C Deng, JK Kirui, H Jiang, J Qin, PW Abel… - Cancer research, 2009 - AACR
Aberrant signaling through G-protein coupled receptors promotes metastasis, the major cause
of breast cancer death. We identified regulator of G-protein signaling 4 (RGS4) as a novel …

[HTML][HTML] Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

P Wei, Y Xie, PW Abel, Y Huang, Q Ma, L Li, J Hao… - Cell death & …, 2019 - nature.com
Transforming growth factor (TGF)-β1, a main profibrogenic cytokine in the progression of
idiopathic pulmonary fibrosis (IPF), induces differentiation of pulmonary fibroblasts to …

TH17 cells and corticosteroid insensitivity in severe asthma

Y Xie, PW Abel, TB Casale, Y Tu - Journal of Allergy and Clinical …, 2022 - Elsevier
Asthma is classically described as having either a type 2 (T2) eosinophilic phenotype or a
non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation …

[PDF][PDF] Comparison of alpha 1-adrenergic receptor subtypes distinguished by chlorethylclonidine and WB 4101.

KP Minneman, C Han, PW Abel - Molecular pharmacology, 1988 - Citeseer
We showed previously that subtypes of a1-adrenergic receptors can be differentiated by
selective inactivation with chlorethylclonidine (CEC)[Mo!. Pharmaco!. 32: 505-51 0 (1 987)] or by …

Quantification of steady state expression of mRNA for alpha-1 adrenergic receptor subtypes using reverse transcription and a competitive polymerase chain reaction.

MA Scofield, F Liu, PW Abel, WB Jeffries - Journal of Pharmacology and …, 1995 - ASPET
Three distinct alpha-1 adrenergic receptor subtypes (alpha-1a, alpha-1b and alpha-1d)
have been identified through molecular cloning. Expression of alpha-1 adrenergic receptor …

Heterogeneity of alpha 1-adrenergic receptors revealed by chlorethylclonidine.

C Han, PW Abel, KP Minneman - Molecular pharmacology, 1987 - ASPET
Chlorethylclonidine (CEC) has previously been shown to inactivate only a subpopulation of
the alpha 1-adrenergic receptor binding sites in rat brain. We compared alpha 1-adrenergic …

Respiratory dysfunction progresses with age in Kcna1‐null mice, a model of sudden unexpected death in epilepsy

…, SA Matthews, M Deodhar, PJ Oldenburg, PW Abel… - …, 2018 - Wiley Online Library
Objective Increased breathing rate, apnea, and respiratory failure are associated with
sudden unexpected death in epilepsy ( SUDEP ). We recently demonstrated the progressive …

Gβγ signaling promotes breast cancer cell migration and invasion

JK Kirui, Y Xie, DW Wolff, H Jiang, PW Abel… - Journal of Pharmacology …, 2010 - ASPET
Signaling through G protein-coupled receptors (GPCRs) promotes breast cancer metastasis.
G proteins convey GPCR signals by dissociating into Gα and Gβγ subunits. The aim of the …