[PDF][PDF] Pharmacokinetic rationale for peritoneal drug administration

RL Dedrick, CE Myers, PM Bungay, VT DeVita - Cancer Treat Rep, 1978 - researchgate.net
Evidence from the peritoneal dialysis literature suggests that the peritoneal permeability of a
number of hydrophilic anticancer drugs may be considerably less than plasma clearance. …

Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro

PM Bungay, PF Morrison, RL Dedrick - Life sciences, 1990 - Elsevier
… Membrane: For low molecular weight water-soluble solutes the accessible volume fraction
of the membrane, ~Pm, is of the order of the volume fraction occupied by water. Diffusion of …

The motion of a closely-fitting sphere in a fluid-filled tube

PM Bungay, H Brenner - International Journal of Multiphase Flow, 1973 - Elsevier
Singular perturbation techniques are used to investigate the slow, asymmetric flow around a
sphere positioned eccentrically within a long, circular, cylindrical tube filled with viscous fluid…

AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives

…, E Benfeldt, J Bolinder, R Bullock, PM Bungay… - 2007 - Springer
… The typical total microdialysate volumes of a few μL or less and analyte concentrations in
the pM or nM range present tremendous challenges for the analytical chemist. Thus, it is …

Microdialysis of dopamine interpreted with quantitative model incorporating probe implantation trauma

PM Bungay, P Newton‐Vinson, W Isele… - Journal of …, 2003 - Wiley Online Library
Although microdialysis is widely used to sample endogenous and exogenous substances in
vivo, interpretation of the results obtained by this technique remains controversial. The goal …

A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide

…, H Kim, S Kim, RJ Lutz, C Galban, PM Bungay… - Experimental eye …, 2006 - Elsevier
Transscleral delivery of triamcinolone acetonide into the vitreous using sub-Tenon's
injections may be a safer alternative to reduce the sight-threatening complications of direct …

Evaluation of coupled convective–diffusive transport of drugs administered by intravitreal injection and controlled release implant

J Park, PM Bungay, RJ Lutz, JJ Augsburger… - Journal of controlled …, 2005 - Elsevier
A 3-dimensional finite element model was developed to simulate pharmacokinetics in the
eye following drug administration by intravitreal injection and implant for the treatment of …

Effects of different semipermeable membranes on in vitro and in vivo performance of microdialysis probes

…, PF Morrison, IN Mefford, PM Bungay - Journal of …, 1990 - Wiley Online Library
… barrels of 500 pm 0.d. 24-gauge TW stainless steel (Small Parts) and inner barrels of 150 pm
0.d… (5 cm long, 1 mm id) packed with 3 pm ODS Hypersil (Shandon) with a mobile phase of …

Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay

…, ML Miller, JJ Diegmueller, PM Bungay… - The American journal of …, 2003 - Elsevier
One of the major problems in angiogenesis research remains the lack of suitable methods for
quantifying the angiogenic response in vivo. We describe the development and application …

[HTML][HTML] Analysis of binding at a single spatially localized cluster of binding sites by fluorescence recovery after photobleaching

BL Sprague, F Müller, RL Pego, PM Bungay… - Biophysical journal, 2006 - cell.com
Cells contain many subcellular structures in which specialized proteins locally cluster.
Binding interactions within such clusters may be analyzed in live cells using models for …