User profiles for P. J. Fletcher
 | Paul J FletcherCentre for Addiction and Mental Health Verified email at camh.net Cited by 13223 |
The amphetamine-induced sensitized state as a model of schizophrenia
Schizophrenia is a serious psychiatric disorder which impacts a broad range of cognitive,
behavioural and emotional domains. In animals, exposure to an intermittent, escalating dose …
behavioural and emotional domains. In animals, exposure to an intermittent, escalating dose …
Serotonin and drug reward: focus on 5-HT2C receptors
GA Higgins, PJ Fletcher - European journal of pharmacology, 2003 - Elsevier
Pharmacological manipulation of the 5-hydroxytryptamine (5-HT; serotonin) system has
long been associated with a regulation of feeding behaviour, however, the initial part of this …
long been associated with a regulation of feeding behaviour, however, the initial part of this …
Myocardial infarct size and ventricular function in rats.
…, JM Pfeffer, MC Fishbein, PJ Fletcher… - Circulation …, 1979 - Am Heart Assoc
To define the relationship between infarct size and ventricular performance, we performed
hemodynamic studies in rats 21 days after left coronary artery occlusion. Ventricular …
hemodynamic studies in rats 21 days after left coronary artery occlusion. Ventricular …
From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists
GA Higgins, EM Sellers, PJ Fletcher - Trends in pharmacological sciences, 2013 - cell.com
The recent US Food and Drug Administration (FDA) approval of the serotonin (5-hydroxytryptamine,
5-HT) 5-HT 2C receptor agonist lorcaserin for the treatment of obesity represents a …
5-HT) 5-HT 2C receptor agonist lorcaserin for the treatment of obesity represents a …
Progressive ventricular remodeling in rat with myocardial infarction
JM Pfeffer, MA Pfeffer, PJ Fletcher… - American Journal of …, 1991 - journals.physiology.org
Ventricular dilatation may have important prognostic implications for the survival of patients
with left ventricular (LV) dysfunction. To determine the manner and extent to which the left …
with left ventricular (LV) dysfunction. To determine the manner and extent to which the left …
Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.
PJ Fletcher, JM Pfeffer, MA Pfeffer… - Circulation …, 1981 - Am Heart Assoc
To determine the effects of healed myocardial infarction on the diastolic compliance of the left
ventricle, we studied 36 rats 26 days after left coronary artery ligation. Peak cardiac output …
ventricle, we studied 36 rats 26 days after left coronary artery ligation. Peak cardiac output …
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
AD Le, B Quan, W Juzytch, PJ Fletcher, N Joharchi… - …, 1998 - Springer
Previous studies using a reinstatement procedure have found that acute reexposure to the
self-administered drug and exposure to footshock stress reinstate heroin and cocaine seeking …
self-administered drug and exposure to footshock stress reinstate heroin and cocaine seeking …
Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats
…, R Raymond, AM Lozano, PJ Fletcher… - Biological …, 2010 - Elsevier
BACKGROUND: Subcallosal cingulate gyrus (SCG) deep brain stimulation (DBS) is being
investigated as a treatment for major depression. We report on the effects of ventromedial …
investigated as a treatment for major depression. We report on the effects of ventromedial …
Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT1A somatodendritic …
…, MG Cascio, S Anavi‐Goffer, PJ Fletcher… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE To evaluate the hypothesis that activation of somatodendritic
5‐HT 1A autoreceptors in the dorsal raphe nucleus (DRN) produces the anti‐emetic/anti‐…
5‐HT 1A autoreceptors in the dorsal raphe nucleus (DRN) produces the anti‐emetic/anti‐…
Cardiac event recorders yield more diagnoses and are more cost-effective than 48-hour Holter monitoring in patients with palpitations: a controlled clinical trial
…, BL Chapman, DB Hardy, PJ Fletcher - Annals of Internal …, 1996 - acpjournals.org
Objective: To compare the diagnostic yield and cost-effectiveness of transtelephonic event
monitors with those of Holter monitoring in patients with intermittent palpitations. Design: …
monitors with those of Holter monitoring in patients with intermittent palpitations. Design: …