… as a basTc solution (pH 11.3) in 0.9% saline in doses from 250 to 1200 mg/kg body welght.
Groups of 12 mice were used at each of the 9 dose levels. The 48-hour mortality for both …

The effects of selenium, vitamin E, and DL-methionine deficiency on the acute lethality and
hepatotoxicity of acetaminophen in male CD-1 mice were studied. Vitamin E and selenium …

… Assays of drug-metabolizing enzyme activity were performed aerobically at 37 in 50 mM
Tris-KC1 buffer (pH 7.4) with saturating concentrations of cofactors and substrates (except in …

… m Mg(OAc)2, 0.05 M NH4CI, 0.001 M dithiothreitol (pH 7.4), and 50% gylcerol for 2 days,
adjusted to 98 mg/ml, and stored at —20 for over 2 years with only slight loss in activity. The …

… at 25 and 37 C at pH 7.0 are 0.024 and 0.096 min™1… pH has allowed the calculation of an
approximate pifa of 6.3 for the tertiary amine, while the influence of reaction conditions (eg, pH…

N-demethylation and 0-de-ethylation of ethylmorphine [6-3H1 by male rat hepatic microsomes.
J. Pharmacol. Exp. Ther. 21 1: 213-218, 1979. A sensitive and convenient radioassay for …

… Here, we report brain activations of 25 scientists with a Ph.D. … to persist, even after completing
a Ph.D. Advanced experts may still … evidence that even experts with a Ph.D. would need to …

… in DMF at pH 8 to 9 using dicyclohexylcarbodiimide (DCC) as the dehydrating agent. The
resulting activated ester was then incubated with BSA or modified BSA in a pH 9 bicarbonate …

… The pH profiles show slightly different maxima (N-demethylation, pH 8.0; O-demethylation,
pH … Further, the differences in the kinetic parameters and the pH profile suggest that these two …

Immunoassays (eg, RIA, EIA) have been demonstrated to be useful for rapid, convenient
detection and semiquantitative analysis of drugs. Thermedics Detection, Inc. manufactures a …