Pharmacology of adenosine receptors: the state of the art
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A 1 , A 2A , A 2B , and A 3 . Due to the rapid …
enrollment of four G protein-coupled receptors: A 1 , A 2A , A 2B , and A 3 . Due to the rapid …
Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility
The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to its …
tissue function especially when energy supply fails to meet cellular energy demand. Due to its …
The A3 adenosine receptor: an enigmatic player in cell biology
…, K Varani, E Leung, S Mac Lennan, PA Borea - Pharmacology & …, 2008 - Elsevier
Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …
The A3 adenosine receptor: history and perspectives
By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular …
regulator of local tissue function, especially when energy supply fails to meet cellular …
A glance at adenosine receptors: novel target for antitumor therapy
…, E Leung, PG Baraldi, MA Tabrizi, PA Borea - Pharmacology & …, 2003 - Elsevier
Adenosine can be released from a variety of cells throughout the body, as the result of increased
metabolic rates, in concentrations that can have a profound impact on the vasculature, …
metabolic rates, in concentrations that can have a profound impact on the vasculature, …
Enthalpy-entropy compensation in drug-receptor binding
P Gilli, V Ferretti, G Gilli, PA Borea - The Journal of Physical …, 1994 - ACS Publications
The thermodynamic parameters (AG, AH0, AS0) of the drug-receptor binding equilibrium
derived from equilibrium constant measurements at different temperatures and van’t Hoff plots …
derived from equilibrium constant measurements at different temperatures and van’t Hoff plots …
[HTML][HTML] Adenosine receptors and cancer
…, S Merighi, V Sacchetto, C Simioni, PA Borea - Biochimica et Biophysica …, 2011 - Elsevier
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A 1 , A 2A , A 2B and …
by its interaction with four G-protein-coupled receptor subtypes, termed A 1 , A 2A , A 2B and …
Elevated Expression of A3 Adenosine Receptors in Human Colorectal Cancer Is Reflected in Peripheral Blood Cells
…, S Gullini, E Leung, S Mac-Lennan, PA Borea - Clinical Cancer …, 2004 - AACR
Purpose: Adenosine is a ubiquitous nucleoside that accumulates at high levels in hypoxic
regions of solid tumors, and A 3 adenosine receptors have been recently demonstrated to play …
regions of solid tumors, and A 3 adenosine receptors have been recently demonstrated to play …
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human …
…, E Leung, S Maclennan, PG Baraldi, PA Borea - Molecular …, 2007 - ASPET
Frequent coffee consumption has been associated with a reduced risk of colorectal cancer
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …