Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A 1 , A 2A , A 2B , and A 3 . Due to the rapid …

Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?

PA Borea, S Gessi, S Merighi, K Varani - Trends in pharmacological …, 2016 - cell.com
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility

PG Baraldi, MA Tabrizi, S Gessi, PA Borea - Chemical reviews, 2008 - ACS Publications
The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to its …

The A3 adenosine receptor: an enigmatic player in cell biology

…, K Varani, E Leung, S Mac Lennan, PA Borea - Pharmacology & …, 2008 - Elsevier
Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

The A3 adenosine receptor: history and perspectives

PA Borea, K Varani, F Vincenzi, PG Baraldi… - Pharmacological …, 2015 - ASPET
By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular …

A glance at adenosine receptors: novel target for antitumor therapy

…, E Leung, PG Baraldi, MA Tabrizi, PA Borea - Pharmacology & …, 2003 - Elsevier
Adenosine can be released from a variety of cells throughout the body, as the result of increased
metabolic rates, in concentrations that can have a profound impact on the vasculature, …

Enthalpy-entropy compensation in drug-receptor binding

P Gilli, V Ferretti, G Gilli, PA Borea - The Journal of Physical …, 1994 - ACS Publications
The thermodynamic parameters (AG, AH0, AS0) of the drug-receptor binding equilibrium
derived from equilibrium constant measurements at different temperatures and van’t Hoff plots …

[HTML][HTML] Adenosine receptors and cancer

…, S Merighi, V Sacchetto, C Simioni, PA Borea - Biochimica et Biophysica …, 2011 - Elsevier
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A 1 , A 2A , A 2B and …

Elevated Expression of A3 Adenosine Receptors in Human Colorectal Cancer Is Reflected in Peripheral Blood Cells

…, S Gullini, E Leung, S Mac-Lennan, PA Borea - Clinical Cancer …, 2004 - AACR
Purpose: Adenosine is a ubiquitous nucleoside that accumulates at high levels in hypoxic
regions of solid tumors, and A 3 adenosine receptors have been recently demonstrated to play …

Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human …

…, E Leung, S Maclennan, PG Baraldi, PA Borea - Molecular …, 2007 - ASPET
Frequent coffee consumption has been associated with a reduced risk of colorectal cancer
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …