Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats

R Rocha, PN Chander, K Khanna, A Zuckerman… - …, 1998 - Am Heart Assoc
… 7 Stier CT Jr, Sim GJ, Mahboubi K, Shen W, Levine S, Chander PN. Prevention of stroke
and … 8 Stier CT Jr, Adler LA, Levine S, Chander PN. Stroke prevention by losartan in stroke-…

Aldosterone as a mediator in cardiovascular injury

CT Stier Jr, PN Chander, R Rocha - Cardiology in review, 2002 - journals.lww.com
The renin-angiotensin-aldosterone system plays a central role in the development of hypertension
and the progression of end-organ damage. Although angiotensin-converting enzyme …

Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats

R Rocha, PN Chander, A Zuckerman, CT Stier Jr - Hypertension, 1999 - Am Heart Assoc
… 7 Stier CT Jr, Chander PN, Gutstein WH, Levine S, Itskovitz HD. Therapeutic benefit of captopril
in … 9 Stier CT Jr, Adler LA, Levine S, Chander PN. Stroke prevention by losartan in stroke-…

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

…, N Labinskyy, S Gupte, PN Chander… - American Journal …, 2008 - journals.physiology.org
Mitochondrial biogenesis is involved in the control of cell metabolism, signal transduction, and
regulation of mitochondrial reactive oxygen species (ROS) production. Despite the central …

Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen

PN Chander, O Gealekman, SV Brodsky… - Journal of the …, 2004 - journals.lww.com
ABSTRACT. Zucker diabetic fat (ZDF) rats with the metabolic syndrome and hyperlipidemia
develop focal and segmental sclerosis. The role of oxidative and nitrosative stress in the …

[HTML][HTML] CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

…, C Suwyn, M Haber, PN Chander… - The Journal of …, 2003 - Am Soc Clin Investig
Systemic lupus erythematosus (SLE) is a CD4+ T cell–dependent, immune complex–mediated,
autoimmune disease that primarily affects women of childbearing age. Generation of high…

Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD

…, JA Zullo, R Chen, J Maizel, PN Chander… - Journal of the …, 2015 - journals.lww.com
Excessive TGF-β signaling in epithelial cells, pericytes, or fibroblasts has been implicated in
CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal …

Collapsing glomerulopathy in 19 patients with systemic lupus erythematosus or lupus-like disease

…, AM Herzenberg, PN Chander… - Clinical journal of the …, 2012 - journals.lww.com
Results Initially, 95% of patients had nephrotic syndrome with proteinuria of 3–12 g per 24
hours, creatinine levels of 0.6–9.6 mg/dl, positive lupus serologies, and normal complement …

[HTML][HTML] HIV promotes NLRP3 inflammasome complex activation in murine HIV-associated nephropathy

…, MA Saleem, W Popik, A Malhotra, PN Chander… - The American journal of …, 2016 - Elsevier
Dysregulated growth and loss of podocytes are important features of HIV-associated nephropathy.
Recently, HIV was reported to induce a new type of programed cell death, pyroptosis, …

Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress

…, L Luan, N Franki, PN Chander… - American Journal …, 2007 - journals.physiology.org
Aldosterone has attracted significant consideration for its role in the progression of renal
injury. Since apoptotic cell loss contributes to the deterioration of renal function, we examined …